1. Ripoll, M.; Pierdant, M.; Neuberg, P.; Bagnard, D.; Wagner, A.; Kichler, A.; Remy, J. S., Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing. Rsc Advances 2018, 8 (37), 20758-20763.
  2. Neuberg, P.; Hamaidi, I.; Danilin, S.; Ripoll, M.; Lindner, V.; Nothisen, M.; Wagner, A.; Kichler, A.; Massfelder, T.; Remy, J. S., Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery. Nanoscale 2018, 10 (4), 1587-1590.
  3. Mariotte, A.; Zhang, Z.; de Cauwer, A.; Frisch, B.; Bahram, S.; Ricci, R.; Georgel, P., Which Place for the Nlrp3 Inflammasome in the Msu Crystal-Induced Inflammatory Response in Vivo? Annals of the rheumatic diseases 2018, 77, A13-A13.
  4. Kporou Kouassi, E.; Ouattara, S.; Seguin, C.; Fournel, S.; Frisch, B., Etude De Quelques Proprietes Biologiques De Ocimum Gratissimum L., Une Lamiaceae Recoltee A Daloa (Côte d'Ivoire). European Scientific Journal 2018, 14 (3), 477-493.
  5. Hardy, A.; Seguin, C.; Brion, A.; Lavalle, P.; Schaaf, P.; Fournel, S.; Bourel-Bonnet, L.; Frisch, B.; De Giorgi, M., beta-Cyclodextrin-Functionalized Chitosan/Alginate Compact Polyelectrolyte Complexes (CoPECs) as Functional Biomaterials with Anti-Inflammatory Properties. ACS Applied Materials and Interfaces 2018, 10 (35), 29347-29356.
  6. Desplancq, D.; Groysbeck, N.; Chiper, M.; Weiss, E.; Frisch, B.; Strub, J. M.; Cianferani, S.; Zafeiratos, S.; Moeglin, E.; Holy, X.; Favier, A. L.; De Carlo, S.; Schultz, P.; Spehner, D.; G., Z., Cytosolic Diffusion and Peptide-Assisted Nuclear Shuttling of Peptide-Substituted Circa 102 Gold Atom Nanoclusters in Living Cells. ACS Applied Nano Materials 2018, 1 (8), 4236-4246.
  7. Bouché, M.; Fournel, S.; Kichler, A.; Selvam, T.; Gallani, J. L.; Bellemin-Laponnaz, S., Straightforward Synthesis of L‐PEI‐Coated Gold Nanoparticles and Their Biological Evaluation. European journal of inorganic chemistry 2018, 2018 (25), 2972-2975.
  8. Bergtold, C.; Hauser, D.; Chaumont, A.; El Yakhlifi, S.; Mateescu, M.; Meyer, F.; Metz-Boutigue, M. H.; Frisch, B.; Schaaf, P.; Ihiawakrim, D.; Ersen, O.; Monnier, C. A.; Petri-Fink, A.; Rothen-Rutishauser, B.; Ball, V., Mimicking the Chemistry of Natural Eumelanin Synthesis: The KE Sequence in Polypeptides and in Proteins Allows for a Specific Control of Nanosized Functional Polydopamine Formation. Biomacromolecules 2018, 19 (9), 3693-3704.
  9. Chekkat, N.; Lombardo, C. M.; Seguin, C.; Lechner, M. C.; Dufour, F.; Nomine, Y.; De Giorgi, M.; Frisch, B.; Micheau, O.; Guichard, G.; Altschuh, D.; Fournel, S., Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes. Oncotarget 2018, 9 (21), 15566-15578.


  1. Zahouani, S.; Hurman, L.; De Giorgi, M.; Vigier-Carriere, C.; Boulmedais, F.; Senger, B.; Frisch, B.; Schaaf, P.; Lavalle, P.; Jierry, L., Step-by-step build-up of covalent poly(ethylene oxide) nanogel films. Nanoscale 2017, 9 (46), 18379-18391.
  2. Zaet, A.; Dartevelle, P.; Daouad, F.; Ehlinger, C.; Quiles, F.; Francius, G.; Boehler, C.; Bergthold, C.; Frisch, B.; Prevost, G.; Lavalle, P.; Schneider, F.; Haikel, Y.; Metz-Boutigue, M. H.; Marban, C., D-Cateslytin, a new antimicrobial peptide with therapeutic potential. Sci Rep 2017, 7 (1), 15199.
  3. Spanedda, M. V.; De Giorgi, M.; Hassane, F. S.; Schuber, F.; Bourel-Bonnet, L.; Frisch, B., Coupling of Ligands to the Liposome Surface by Click Chemistry. Methods Mol Biol 2017, 1522, 93-106.
  4. Smulski, C. R.; Decossas, M.; Chekkat, N.; Beyrath, J.; Willen, L.; Guichard, G.; Lorenzetti, R.; Rizzi, M.; Eibel, H.; Schneider, P.; Fournel, S., Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling. Cell Death Dis 2017, 8 (2), e2601.
  5. Saliba, H.; Heurtault, B.; Bouharoun-Tayoun, H.; Flacher, V.; Frisch, B.; Fournel, S.; Chamat, S., Enhancing tumor specific immune responses by transcutaneous vaccination. Expert Rev Vaccines 2017.
  6. Phoeung, T.; Spanedda, M. V.; Roger, E.; Heurtault, B.; Foumel, S.; Reisch, A.; Mutschler, A.; Perrin-Schmitt, F.; Hemmerle, J.; Collin, D.; Rawiso, M.; Boulmedais, F.; Schaaf, P.; Lavalle, P.; Frisch, B., Alginate/Chitosan Compact Polyelectrolyte Complexes: A Cell and Bacterial Repellent Material. Chem Mater 2017, 29 (24), 10418-10425.
  7. Nicolas-Boluda, A.; Silva, A. K. A.; Fournel, S.; Gazeau, F., Physical oncology: New targets for nanomedicine. Biomaterials 2017, 150, 87-99.
  8. Macho-Fernandez, E.; Chekkat, N.; Ehret, C.; Thomann, J. S.; De Giorgi, M.; Spanedda, M. V.; Bourel-Bonnet, L.; Betbeder, D.; Heurtault, B.; Faveeuw, C.; Fournel, S.; Frisch, B.; Trottein, F., Solubilization of alpha-galactosylceramide in aqueous medium: Impact on Natural Killer T cell activation and antitumor responses. Int J Pharm 2017, 530 (1-2), 354-363.
  9. Gossart, J. B.; Pascal, E.; Meyer, F.; Heuillard, E.; Goncalves, M.; Gosse, F.; Robinet, E.; Frisch, B.; Seguin, C.; Zuber, G., Performance of Pyridylthiourea-Polyethylenimine Polyplex for siRNA-Mediated Liver Cancer Therapy in Cell Monolayer, Spheroid, and Tumor Xenograft Models. Glob Chall 2017, 1 (4).
  10. Fogha, J.; Marekha, B.; De Giorgi, M.; Voisin-Chiret, A. S.; Rault, S.; Bureau, R.; Sopkova-de Oliveira Santos, J., Toward Understanding Mcl-1 Promiscuous and Specific Binding Mode. J Chem Inf Model 2017, 57 (11), 2885-2895.


  1. Roux, M. J.; Cottineau, T.; Keller, V.; Keller, N.; Ronzani, C., High frequency stimulations of wild type and blind mouse retinas using titanium dioxide nanotubes as artificial photoreceptors. Invest Ophth Vis Sci 2016, 57 (12).
  2. Pierrat, P.; Kereselidze, D.; Lux, M.; Lebeau, L.; Pons, F., Enhanced gene delivery to the lung using biodegradable polyunsaturated cationic phosphatidylcholine-detergent conjugates. Int J Pharm 2016, 511 (1), 205-18.
  3. Pierrat, P.; Casset, A.; Kereselidze, D.; Lux, M.; Pons, F.; Lebeau, L., DOPC-Detergent Conjugates: Fusogenic Carriers for Improved In Vitro and In Vivo Gene Delivery. Macromol Biosci 2016, 16 (7), 984-9.
  4. Pierrat, P.; Casset, A.; Didier, P.; Kereselidze, D.; Lux, M.; Pons, F.; Lebeau, L., Cationic DOPC-Detergent Conjugates for Safe and Efficient in Vitro and in Vivo Nucleic Acid Delivery. Chembiochem : a European journal of chemical biology 2016, 17 (18), 1771-83.
  5. Neila Chekkat, C. M. L., Marie-Charlotte Lechner, Cendrine Seguin, Florent Dufour, Benoit Frisch, Olivier Micheau, Gilles Guichard, Danièle Altschuh*, Sylvie Fournel*, Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes.  Oncotarget 2016.
  6. Kakhi, Z.; Frisch, B.; Heurtault, B.; Pons, F., Liposomal constructs for antitumoral vaccination by the nasal route. Biochimie 2016, 130, 14-22.
  7. Fend, L.; Remy-Ziller, C.; Foloppe, J.; Kempf, J.; Cochin, S.; Barraud, L.; Accart, N.; Erbs, P.; Fournel, S.; Preville, X., Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor microenvironment. Oncoimmunology 2016, 5 (2), e1080414.
  8. Diab, R.; Virriat, A. S.; Ronzani, C.; Fontanay, S.; Grandemange, S.; Elaissari, A.; Foliguet, B.; Maincent, P.; Leroy, P.; Duvaj, R. E.; Rihn, B. H.; Joubert, O., Elaboration of Sterically Stabilized Liposomes for S-Nitrosoglutathione Targeting to Macrophages. J Biomed Nanotechnol 2016, 12 (1), 217-30.
  9. Chekkat, N.; Dahm, G.; Chardon, E.; Wantz, M.; Sitz, J.; Decossas, M.; Lambert, O.; Frisch, B.; Rubbiani, R.; Gasser, G.; Guichard, G.; Fournel, S.; Bellemin-Laponnaz, S., N-Heterocyclic Carbene-Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy. Bioconjug Chem 2016, 27 (8), 1942-8.
  10. Casset, A.; Khayath, N.; de Blay, F., How In Vitro Assays Contribute to Allergy Diagnosis. Curr Allergy Asthma Rep 2016, 16 (11), 82.
  11. Bouche, M.; Dahm, G.; Wantz, M.; Fournel, S.; Achard, T.; Bellemin-Laponnaz, S., Platinum(iv) N-heterocyclic carbene complexes: their synthesis, characterisation and cytotoxic activity. Dalton Trans 2016, 45 (28), 11362-8.
  12. Beyrath, J.; Chekkat, N.; Smulski, C. R.; Lombardo, C. M.; Lechner, M. C.; Seguin, C.; Decossas, M.; Spanedda, M. V.; Frisch, B.; Guichard, G.; Fournel, S., Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels. Oncotarget 2016.
  13. Barthelemy, A.; Ivanov, S.; Hassane, M.; Fontaine, J.; Heurtault, B.; Frisch, B.; Faveeuw, C.; Paget, C.; Trottein, F., Exogenous Activation of Invariant Natural Killer T Cells by alpha-Galactosylceramide Reduces Pneumococcal Outgrowth and Dissemination Postinfluenza. MBio 2016, 7 (6).


  1. Vittoria Spanedda, M.; Salome, C.; Hilbold, B.; Berner, E.; Heurtault, B.; Fournel, S.; Frisch, B.; Bourel-Bonnet, L., Smart tools and orthogonal click-like reactions onto small unilamellar vesicles: Additional molecular data. Data Brief 2015, 5, 145-154.
  2. Salome, C.; Spanedda, M. V.; Hilbold, B.; Berner, E.; Heurtault, B.; Fournel, S.; Frisch, B.; Bourel-Bonnet, L., Smart tools and orthogonal click-like reactions onto small unilamellar vesicles. Chem Phys Lipids 2015, 188, 27-36.
  3. Rios, C.; Longo, J.; Zahouani, S.; Garnier, T.; Vogt, C.; Reisch, A.; Senger, B.; Boulmedais, F.; Hemmerle, J.; Benmlih, K.; Frisch, B.; Schaaf, P.; Jierry, L.; Lavalle, P., A new biomimetic route to engineer enzymatically active mechano-responsive materials. Chem Commun (Camb) 2015, 51 (26), 5622-5.
  4. Pulka-Ziach, K.; Pavet, V.; Chekkat, N.; Estieu-Gionnet, K.; Rohac, R.; Lechner, M. C.; Smulski, C. R.; Zeder-Lutz, G.; Altschuh, D.; Gronemeyer, H.; Fournel, S.; Odaert, B.; Guichard, G., Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation. Chembiochem : a European journal of chemical biology 2015, 16 (2), 293-301.
  5. Pierrat, P.; Wang, R.; Kereselidze, D.; Lux, M.; Didier, P.; Kichler, A.; Pons, F.; Lebeau, L., Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers. Biomaterials 2015, 51, 290-302.
  6. Kakhi, Z.; Frisch, B.; Bourel-Bonnet, L.; Hemmerle, J.; Pons, F.; Heurtault, B., Airway administration of a highly versatile peptide-based liposomal construct for local and distant antitumoral vaccination. Int J Pharm 2015, 496 (2), 1047-56


  1. Ronzani, C.; Casset, A.; Pons, F., Exposure to multi-walled carbon nanotubes results in aggravation of airway inflammation and remodeling and in increased production of epithelium-derived innate cytokines in a mouse model of asthma. Arch Toxicol 2014, 88 (2), 489-99.
  2. Reisch, A.; Roger, E.; Phoeung, T.; Antheaume, C.; Orthlieb, C.; Boulmedais, F.; Lavalle, P.; Schlenoff, J. B.; Frisch, B.; Schaaf, P., On the Benefits of Rubbing Salt in the Cut: Self-Healing of Saloplastic PAA/PAH Compact Polyelectrolyte Complexes. Advanced materials 2014, 26 (16), 2547-51.
  3. Pinel, S.; Aman, E.; Erblang, F.; Dietrich, J.; Frisch, B.; Sirman, J.; Kichler, A.; Sibler, A. P.; Dontenwill, M.; Schaffner, F.; Zuber, G., Quantitative measurement of delivery and gene silencing activities of siRNA polyplexes containing pyridylthiourea-grafted polyethylenimines. Journal of controlled release 2014, 182C, 1-12.
  4. Macho-Fernandez, E.; Cruz, L. J.; Ghinnagow, R.; Fontaine, J.; Bialecki, E.; Frisch, B.; Trottein, F.; Faveeuw, C., Targeted delivery of alpha-galactosylceramide to CD8alpha+ dendritic cells optimizes type I NKT cell-based antitumor responses. J Immunol 2014, 193 (2), 961-9.
  5. Heurtault, B.; Reix, N.; Meyer, N.; Gasser, F.; Wendling, M. J.; Ratomponirina, C.; Jeandidier, N.; Sapin, R.; Agin, A., Extensive study of human insulin immunoassays: promises and pitfalls for insulin analogue detection and quantification. Clin Chem Lab Med 2014, 52 (3), 355-62.
  6. Fend, L.; Gatard-Scheikl, T.; Kintz, J.; Gantzer, M.; Schaedler, E.; Rittner, K.; Cochin, S.; Fournel, S.; Preville, X., Intravenous Injection of MVA Virus Targets CD8+ Lymphocytes to Tumors to Control Tumor Growth upon Combinatorial Treatment with a TLR9 Agonist. Cancer Immunol Res 2014.
  7. Attia, M. F.; Anton, N.; Chiper, M.; Akasov, R.; Anton, H.; Messaddeq, N.; Fournel, S.; Klymchenko, A. S.; Mely, Y.; Vandamme, T. F., Biodistribution of x-ray iodinated contrast agent in nano-emulsions is controlled by the chemical nature of the oily core. ACS nano 2014, 8 (10), 10537-50.


  1. Weghofer, M.; Grote, M.; Resch, Y.; Casset, A.; Kneidinger, M.; Kopec, J.; Thomas, W. R.; Fernandez-Caldas, E.; Kabesch, M.; Ferrara, R.; Mari, A.; Purohit, A.; Pauli, G.; Horak, F.; Keller, W.; Valent, P.; Valenta, R.; Vrtala, S., Identification of Der p 23, a Peritrophin-like Protein, as a New Major Dermatophagoides pteronyssinus Allergen Associated with the Peritrophic Matrix of Mite Fecal Pellets. J Immunol 2013, 190 (7), 3059-3067.
  2. Tirado, P.; Reisch, A.; Roger, E.; Boulmedais, F.; Jierry, L.; Lavalle, P.; Voegel, J.-C.; Schaaf, P.; Schlenoff, J.; Frisch, B., Catalytic Saloplastics: Alkaline Phosphatase Immobilized and Stabilized in Compacted Polyelectrolyte Complexes. Adv. Funct. Mater. 2013, 23 (38), 4785-4792.
  3. Smulski, C. R.; Beyrath, J.; Decossas, M.; Chekkat, N.; Wolff, P.; Estieu-Gionnet, K.; Guichard, G.; Speiser, D.; Schneider, P.; Fournel, S., Cysteine-rich domain 1 of CD40 mediates receptor self-assembly. The Journal of biological chemistry 2013, 288 (15), 10914-22.
  4. Rydzek, G.; Garnier, T.; Schaaf, P.; Voegel, J. C.; Senger, B.; Frisch, B.; Haikel, Y.; Petit, C.; Schlatter, G.; Jierry, L.; Boulmedais, F., Self-construction of supramolecular polyrotaxane films by an electrotriggered morphogen-driven process. Langmuir 2013.
  5. Reix, N.; Sigrist, S.; Heurtault, B.; Agin, A.; Moreau, F.; Pinget, M.; Jeandidier, N., Glycemic management of diabetes by insulin therapy. Minerva endocrinologica 2013, 38 (1), 29-46.
  6. Reix, N.; Massart, C.; d'Herbomez, M.; Gasser, F.; Heurtault, B.; Agin, A., Thyroid-stimulating hormone and free thyroxine on the ADVIA Centaur immunoassay system: a multicenter assessment of analytical performance. Clinical biochemistry 2013, 46 (13-14), 1305-8.
  7. Reisch, A.; Tirado, P.; Roger, E.; Boulmedais, F.; Collin, D.; Voegel, J.-C.; Frisch, B.; Schaaf, P.; Schlenoff, J., Compact Saloplastic Poly(Acrylic Acid)/Poly(Allylamine) Complexes: Kinetic Control Over Composition, Microstructure, and Mechanical Properties. Adv. Funct. Mater. 2013, 23 (6), 673-682.
  8. Pierrat, P.; Laverny, G.; Creusat, G.; Wehrung, P.; Strub, J. M.; VanDorsselaer, A.; Pons, F.; Zuber, G.; Lebeau, L., Phospholipid-Detergent Conjugates as Novel Tools for siRNA Delivery. Chem-Eur J 2013, 19 (7), 2344-2355.
  9. Pierrat, P.; Kereselidze, D.; Wehrung, P.; Zuber, G.; Pons, F.; Lebeau, L., Bioresponsive Deciduous-Charge Amphiphiles for Liposomal Delivery of DNA and siRNA. Pharm Res-Dordr 2013, 30 (5), 1362-1379.
  10. Philippe, L.; Alsaleh, G.; Pichot, A.; Ostermann, E.; Zuber, G.; Frisch, B.; Sibilia, J.; Pfeffer, S.; Bahram, S.; Wachsmann, D.; Georgel, P., MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes. Annals of the rheumatic diseases 2013, 72 (6), 1071-9.
  11. Laverny, G.; Casset, A.; Purohit, A.; Schaeffer, E.; Spiegelhalter, C.; de Blay, F.; Pons, F., Immunomodulatory properties of multi-walled carbon nanotubes in peripheral blood mononuclear cells from healthy subjects and allergic patients. Toxicol Lett 2013, 217 (2), 91-101.
  12. Lamanna, G.; Smulski, C. R.; Chekkat, N.; Estieu-Gionnet, K.; Guichard, G.; Fournel, S.; Bianco, A., Multimerization of an apoptogenic TRAIL-mimicking peptide by using adamantane-based dendrons. Chemistry 2013, 19 (5), 1762-8.
  13. Kastner, P. E.; Le Calve, S.; Zheng, W. Y.; Casset, A.; Pons, F., A dynamic system for single and repeated exposure of airway epithelial cells to gaseous pollutants. Toxicol in Vitro 2013, 27 (2), 632-640.
  14. Grandemange, E.; Fournel, S.; Woehrle, F., Efficacy and safety of cimicoxib in the control of perioperative pain in dogs. J Small Anim Pract 2013, 54 (6), 304-12.
  15. Gentine, P.; Bourel-Bonnet, L.; Frisch, B., Modified and derived ethanol injection toward liposomes: development of the process. Journal of liposome research 2013, 23 (1), 11-9.
  16. Fend, L.; Accart, N.; Kintz, J.; Cochin, S.; Reymann, C.; Le Pogam, F.; Marchand, J. B.; Menguy, T.; Slos, P.; Rooke, R.; Fournel, S.; Bonnefoy, J. Y.; Preville, X.; Haegel, H., Therapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts. PLoS One 2013, 8 (9), e73310.
  17. Devarasu, T.; Saad, R.; Ouadi, A.; Frisch, B.; Robinet, E.; Laquerriere, P.; Voegel, J. C.; Baumert, T.; Ogier, J.; Meyer, F., Potent calcium phosphate nanoparticle surface coating for in vitro and in vivo siRNA delivery: a step toward multifunctional nanovectors. Journal of Materials Chemistry B 2013, 1 (36), 4692-4700.
  18. Casset, A.; Valenta, R.; Vrtala, S., Allergen content and in vivo allergenic activity of house dust mite extracts. International archives of allergy and immunology 2013, 161 (3), 287-8.
  19. Bohren, Y.; Tessier, L. H.; Megat, S.; Petitjean, H.; Hugel, S.; Daniel, D.; Kremer, M.; Fournel, S.; Hein, L.; Schlichter, R.; Freund-Mercier, M. J.; Yalcin, I.; Barrot, M., Antidepressants suppress neuropathic pain by a peripheral beta2-adrenoceptor mediated anti-TNFalpha mechanism. Neurobiol Dis 2013, 60, 39-50.
  20. Barnig, C.; Reboux, G.; Roussel, S.; Casset, A.; Sohy, C.; Dalphin, J. C.; de Blay, F., Indoor dust and air concentrations of endotoxin in urban and rural environments. Letters in applied microbiology 2013, 56 (3), 161-7.
  21. Barnig, C.; Purohit, A.; Casset, A.; Sohy, C.; Lieutier-Colas, F.; Sauleau, E.; de Blay, F., Nonallergic Airway Hyperresponsiveness and Allergen-Specific IgE Levels Are the Main Determinants of the Early and Late Asthmatic Response to Allergen. J Invest Allerg Clin 2013, 23 (4), 267-274.
  22. Bacharouche, J.; Badique, F.; Fahs, A.; Spanedda, M. V.; Geissler, A.; Malval, J. P.; Vallat, M. F.; Anselme, K.; Francius, G.; Frisch, B.; Hemmerle, J.; Schaaf, P.; Roucoules, V., Biomimetic cryptic site surfaces for reversible chemo- and cyto-mechanoresponsive substrates. ACS nano 2013, 7 (4), 3457-65.