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Productions 2012

- Donato, L., Mourot, A., Davenport, C.M., Herbivo, C., Warther, D., Leonard, J., Bolze, F., Nicoud, J.F., Kramer, R.H., Goeldner, M., and Specht, A. (2012) Water-soluble, donor-acceptor biphenyl derivatives in the 2-(o-nitrophenyl)propyl series : Highly efficient two-photon uncaging of the neurotransmitter g-aminobutyric acid at 800 nm. Ang. Chem. Int. Ed. Engl. 51, 1840-1843.
- Loerinczi, E., Bhargava, Y., Marino, S.F., Taly, A., Kaczmarek-Hajek, K., Barrantes-Freer, A., Dutertre, S., Grutter, T., Rettinger, J., and Nicke, A. (2012) Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor. Proc. Natl. Acad. Sci. U. S. A. 109, 11396-11401.
- Lemoine, D., Jiang, R., Taly, A., Chataigneau, T., Specht, A., and Grutter, T. (2012) Ligand-gated ion channels : New insights into neurological disorders and ligand recognition. Chem. Rev. 112, 6285-6318.
- Jiang, R., Taly, A., Lemoine, D., Martz, A., Specht, A., and Grutter, T. (2012) Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor. Channels 6, 398-402.
- Specht, A., Bolze, F., Donato, L., Herbivo, C., Charon, S., Warther, D., Gug, S., Nicoud, J.F., and Goeldner, M. (2012) The donor-acceptor biphenyl platform : Aversatile chromophore for the engineering of highly efficient two-photon sensitive photoremovable protecting groups. Photochem. Photobiol. Sci. 11, 578-586.
- Bolze, F., Nicoud, J.F., Bourgogne, C., Gug, S., Sun, X.H., Goeldner, M., Specht, A., Donato, L., Warther, D., Turi, G.F., and Losonczy, A. (2012) Two-photon uncaging : The chemist point of view. Opt. Mater. 34, 1664- 1669.
- Jiang, R., Taly, A., Lemoine, D., Martz, A., Cunrath, O., and Grutter, T. (2012) Tightening of the ATP-binding sites induces the opening of P2X receptor channels. EMBO J. 31, 2134-2143.
- Lux, J., Pena, E.J., Bolze, F., Heinlein, M., and Nicoud, J.F. (2012) Malachite green derivatives for twophoton RNA detection. ChemBioChem 13, 1206-1213.
- Lovett-Barron, M., Turi, G. F., Kaifosh, P., Lee, P. H., Bolze, F., Sun, X.-H., Nicoud, J.F., Zemelman, B. V., Sternson, S.M., and Losonczy, A. (2012) Regulation of neuronal input transformations by tunable dendritic inhibition. Nature Neurosci. 15, 423-U111.
- Behr, J.P. (2012) Synthetic gene transfer vectors II : Back to the future. Acc. Chem. Res. 45, 980-984.
- Creusat, G., Thomann, J.S., Maglott, A., Pons, B., Dontenwill, M., Guerin, E., Frisch, B., and Zuber, G. (2012) Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo. J. Control. Release 157, 418-26.
- Gerard, X., Perrault, I., Hanein, S., Silva, E., Bigot, K., Defoort-Delhemmes, S., Rio, M., Munnich, A., Scherman, D., Kaplan, J., Kichler, A., and Rozet, J.M. (2012) AON-mediated exon skipping restores ciliation in fibroblasts harboring the common Leber congenital amaurosis CEP290 mutation. Mol. Ther. Nucleic Acids 1, e29.
- Guiraud, S., van Wittenberghe, L., Georger, C., Scherman, D., and Kichler, A. (2012) Identification of decorin derived peptides with a zinc dependent anti-myostatin activity. Neuromuscul. Disord. 22, 1057-68.
- Iacobucci, V., Di Giuseppe, F., Bui, T. T., Vermeer, L. S., Patel, J., Scherman, D., Kichler, A., Drake, A. F., and Mason, A. J. (2012) Control of pH responsive peptide self-association during endocytosis is required for effective gene transfer. Biochim. Biophys. Acta 1818, 1332-41.
- Paris, C., Moreau, V., Deglane, G., Karim, L., Couturier, B., Bonnet, M.-E., Kedinger, V., Messmer, M., Bolcato-Bellemin, A.-L., Behr, J.P., Erbacher, P., and Lenne-Samuel, N. (2012) Conjugating phosphospermines to siRNAs for improved stability in serum, intracellular delivery and RNAi-mediated gene silencing. Mol. Pharm. 9, 3464-3475.
- Pierrat, P., Creusat, G., Laverny, G., Pons, F., Zuber, G., and Lebeau, L. (2012) A cationic phospholipiddetergent conjugate as a new efficient carrier for siRNA delivery. Chem.-Eur. J. 18, 3835-3839.
- Ronzani, C., Spiegelhalter, C., Vonesch, J.L., Lebeau, L., and Pons, F. (2012) Lung deposition and toxicological responses evoked by multi-walled carbon nanotubes dispersed in a synthetic lung surfactant in the mouse. Arch. Toxicol. 86, 137-149.
- Wintgens, V., Leborgne, C., Baconnais, S., Burckbuchler, V., Le Cam, E., Scherman, D., Kichler, A., and Amiel, C. (2012) Smart DNA vectors based on cyclodextrin polymers : compaction and endosomal release. Pharm. Res. 29, 384-96.
- Yu, T., Liu, X., Bolcato-Bellemin, A. L., Wang, Y., Liu, C., Erbacher, P., Qu, F., Rocchi, P., Behr, J.P., and Peng, L. (2012) An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo. Angew. Chem. Int. Ed. Engl. 51, 8478-8484.
- Kaaki, K., Hervé, K., Chiper, M., Shkilnyy, A., Soucé, M., Benoit, R., Paillard, A., Dubois, P., Saboungi, M.L., Chourpa, I. (2012) Magnetic nanocarriers of doxorubicin coated with poly(ethylene glycol) and folic acid : relation between coating structure, surface properties, colloidal stability and cancer cell targeting. Langmuir 28, 1496-1505.
- Creusat, G., Thomann, J.S., Maglott, A., Pons, B., Dontenwill, M., Guérin, E., Frisch, B., and Zuber, G. (2012) Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo. J. Control. Release 157, 418-426.
- Pierrat, P., Creusat, G., Laverny, G., Pons, F., Zuber, G., and Lebeau, L. (2012) A cationic phospholipiddetergent conjugate as a new efficient carrier for siRNA delivery. Chemistry 18, 3835-3839.
- Souilem, I., Muller, R., Holl, Y., Bouquey, M., Serra, C.A., Vandamme, T.F., and Anton, N. (2012) A Novel Low-Pressure Device for Production of Nanoemulsions. Chem. Eng. Technol. 35, 1692-1698.
- Schante, C.E., Zuber, G., Herlin, C., and Vandamme, T.F. (2012) Improvement of hyaluronic acid enzymatic stability by the grafting of amino-acids. Carbohydr. Polym. 87, 2211-2216.
- Qusaj, Y., Leng, A., Alshihabi, F., Krasniqi, B., and Vandamme, T.F. (2012) Development strategies for herbal products reducing the influence of natural variance in dry mass on tableting properties and tablet characteristics. Pharmaceutics 4, 501-516.
- Klymchenko, A.S., Roger, E., Anton, N., Anton, H., Shulov, I., Vermot, J., Mely, Y., and Vandamme, T.F. (2012) Highly lipophilic fluorescent dyes in nano-emulsions : towards bright non-leaking nano-droplets. RSC Adv. 2, 11876-11886.
- Jakhmola, A., Anton, N., and Vandamme, T.F. (2012) Inorganic nanoparticles based contrast agents for x-ray computed tomography. Adv. Healthcare Mater. 1, 413-431.
- Gbassi, G.K., and Vandamme, T.F. (2012) Probiotic encapsulation technology : From microencapsulation to release into the gut. Pharmaceutics 4, 149-163.
- Bally, F., Garg, D.K., Serra, C.A., Hoarau, Y., Anton, N., Brochon, C., Parida, D., Vandamme, T.F., and Hadziioannou, G. (2012) Improved size-tunable preparation of polymeric nanoparticles by microfluidic nanoprecipitation. Polymer 53, 5045-5051.
- Anton, N., Jakhmola, A., and Vandamme, T.F. (2012) Trojan microparticles for drug delivery. Pharmaceutics 4, 1-25.
- Anton, N., de Crevoisier, A., Schmitt, S., and Vandamme, T.F. (2012) A new application of lipid nanoemulsions as coating agent, providing zero-order hydrophilic drug release from tablets. J. Drug Deliv. 2012, 271319-271319.
- Anton, N., Bally, F., Serra, C. A., Ali, A., Arntz, Y., Mely, Y., Zhao, M., Marchioni, E., Jakhmola, A., and Vandamme, T.F. (2012) A new microfluidic setup for precise control of the polymer nanoprecipitation process and lipophilic drug encapsulation. Soft Matter 8, 10628-10635.
- Alshihabi, F., Vandamme, T.F., and Betz, G. (2012) Predicting physical properties of pharmaceutical compacts using focused beam reflectance measurement (FBRM). J. Drug Deliv. Sci. Technol. 22, 522-530.
- Vrignaud, S., Anton, N., Gayet, P., Benoit, J.P., and Saulnier, P. (2011) Reverse micelle-loaded lipid nanocarriers : A novel drug delivery system for the sustained release of doxorubicin hydrochloride. Eur. J. Pharm. Biopharm. 79, 197-204.
- Egea, P.F., Muller-Steffner, H., Kuhn, I., Cakir-Kiefer, C., Oppenheimer, N.J., Stroud, R.M., Kellenberger, E., and Schuber, F. (2012) Insights into the mecanism of bovine CD38/NAD+glycohydrolase from X-ray stuctures of its mickaelis complex and covalently-trapped intermediates. PLoS One 7, e34918.
- Leriche, G., Chisholm, L., Wagner, A. (2012) Cleavable linkers in chemical biology. Bioorg. Med. Chem. 20, 571-5082.
- Bui The Thuong, M., Catala, C., Colas, C., Schaeffer, C., Van Dorsselaer, A., Mann, A., and Wagner, A. (2012) Trimethoxyarene, a Highly Ionisable Tag for Reaction Analysis by APPI/MS : Exploration of Heterocyclic. Synthesis. Eur. J. Org. Chem., 85-92.
- Bui The Thuong, M., Mann, A., and Wagner, A. (2012) Mild chemo-selective hydration of terminal alkynes catalyzed by AgSbF6. Chem. Commun. 48, 434-436.
- Leriche, G., Budin, G., Darwich, Z., Weltin, D., Mély, Y., Klymchenko, A.S., and Wagner, A. (2012) A FRET based probe with a chemically deactivatable quencher. Chem. Commun. 48, 3224-3226
- Varenne, F., Bourdillon, M., Meyer, M., Lin, Y., Brellier, M., Baati, R., Charbonnière, L.J., Wagner, A., Doris, E., Taran, F., and Hagège, A. (2012) Capillary electrophoresis–inductively coupled plasma-mass spectrometry hyphenation for the determination at the nanogram scale of metal affinities and binding constants of phosphorylated ligands. J. Chromatogr. A 1229, 280–287.
- Dehuyser, L., Schaeffer, E., Chaloin, O., Mueller, C.G., Baati, R., and Wagner, A. (2012) Synthesis of novel mannoside glycolipid conjugates for inhibition of HIV-1 trans-infection. Bioconjugate Chem. 23, 1731–1739.
- King, M., Baati, R., and Wagner, A. (2012) New tetramethylthiepinium (TMTI) for copper-free click chemistry. Chem. Commun. 48, 9308–9309.
- De Talance, V.L., Massinon, O., Baati, R., Wagner, A., and Vincent, S.P. (2012) First steps towards conformationally selective artificial lectins : The chair-boat discrimination by molecularly imprinted polymers. Chem. Commun. 48, 10684-10686.
- Lebon, F., Pegurier, C., Ledecq, M., Mathieu, B., Bosman, N, Frycia, A., Lengele, S., Dhurke, K., Ananda, K.K., Meunier, S., Wagner, A., and Provins, L. (2012) Towards a KCC2 blocker pharmacophore model. Bioorg. Med. Chem. Lett. 22, 3978-3982.
- Rydzek, G., Polavarapu, P., Rios, C., Tisserant, J. N., Voegel, J. C., Senger, B., Lavalle, P., Frisch, B., Schaaf, P., Boulmedais, F., and Jierry, L. (2012) Morphogen-driven self-construction of covalent films built from polyelectrolytes and homobifunctional spacers : buildup and pH response. Soft Matter. 8, 10336-10343.
- Rydzek, G., Parat, A., Polavarapu, P., Baehr, C., Voegel, J. C., Hemmerle, J., Senger, B., Frisch, B., Schaaf, P., Jierry, L., and Boulmedais, F. (2012) One-pot morphogen driven self-constructing films based on noncovalent host-guest interactions. Soft Matter. 8, 446-453.
- Ronzani, C., Spiegelhalter, C., Vonesch, J. L., Lebeau, L., and Pons, F. (2012) Lung deposition and toxicological responses evoked by multi-walled carbon nanotubes dispersed in a synthetic lung surfactant in the mouse. Arch. Toxicol. 86, 137-149.
- Reix, N., Massart, C., Gasser, F., Heurtault, B., and Agin, A. (2012) Should functional sensitivity of a new thyroid stimulating hormone immunoassay be monitored routinely ? The ADVIA Centaur TSH3-UL assay experience. Clin. Biochem. 45, 1260-2.
- Ivanov, S., Fontaine, J., Paget, C., Fernandez, E. M., Van Maele, L., Renneson, J., Maillet, I., Wolf, N. M., Rial, A., Leger, H., Ryffel, B., Frisch, B., Chabalgoity, J. A., Sirard, J. C., Benecke, A., Faveeuw, C., and Trottein, F. (2012) Key role for respiratory CD103(+) dendritic cells, IFN-gamma, and IL-17 in protection against Streptococcus pneumoniae infection in response to alpha-galactosylceramide. J. Infect. Dis. 206, 723- 734.
- Gentine, P., Bubel, A., Crucifix, C., Bourel-Bonnet, L., and Frisch, B. (2012) Manufacture of liposomes by isopropanol injection : characterization of the method. J. Liposome Res. 22, 18-30.
- Casset, A., Mari, A., Purohit, A., Resch, Y., Weghofer, M., Ferrara, R., Thomas, W. R., Alessandri, C., Chen, K. W., de Blay, F., Valenta, R., and Vrtala, S. (2012) Varying allergen composition and content affects the in vivo allergenic activity of commercial Dermatophagoides pteronyssinus extracts. Int. Arch. Allergy Immunol. 159, 253-262.
- Becker, J., Delayre-Orthez, C., Frossard, N., and Pons, F. (2012) The peroxisome proliferator-activated receptor alpha agonist fenofibrate decreases airway reactivity to methacholine and increases endothelial nitric oxide synthase phosphorylation in mouse lung. Fund. Clin. Pharmacol. 26, 340-346.
- Barnig, C., and Casset, A. (2012) Respiratory allergens and asthma exacerbation. Rev. Mal. Respir. 29, 810-819.
- Thomann, J.S., Monneaux, F., Creusat, G., Spanedda, M.V., Heurtault, B., Habermacher, C., Schuber, F., Bourel-Bonnet, L., and Frisch, B. (2012) Novel glycolipid TLR2 ligands of the type Pam2Cys-alpha-Gal : synthesis and biological properties. Eur. J. Med. Chem. 51, 174-83.
- Roger, E., Kalscheuer, S., Kirtane, A., Guru, B. R., Grill, A. E., Whittum-Hudson, J., and Panyam, J. (2012) Folic acid functionalized nanoparticles for enhanced oral drug delivery. Mol. Pharm. 9, 2103-2110.
- Macho Fernandez, E., Chang, J., Fontaine, J., Bialecki, E., Rodriguez, F., Werkmeister, E., Krieger, V., Ehret, C., Heurtault, B., Fournel, S., Frisch, B., Betbeder, D., Faveeuw, C., and Trottein, F. (2012), Activation of invariant Natural Killer T lymphocytes in response to the alpha-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nanoparticles and microparticles. Int. J. Pharm. 423, 45-54.
- Estieu-Gionnet, K., Odaert, B., Smulski, C., Pavet, V., Fournel, S., Gronemeyer, H., and Guichard, G. (2012) Desulfurisation of a cyclic peptide targeting Death Receptor 5 : Conformational outcome and consequences on biological properties. J. Pept. Sci. 18, S104-S104.
- Davila, J., Chassepot, A., Longo, J., Boulmedais, F., Reisch, A., Frisch, B., Meyer, F., Voegel, J. C., Mesini, P. J., Senger, B., Metz-Boutigue, M. H., Hemmerle, J., Lavalle, P., Schaaf, P., and Jierry, L. (2012) Cytomechanoresponsive polyelectrolyte multilayer films. J. Am. Chem. Soc. 134, 83-86.
- Chassepot, A., Gao, L.C., Nguyen, I., Dochter, A., Fioretti, F., Menu, P., Kerdjoudj, H., Baehr, C., Schaaf, P., Voegel, J.C., Boulmedais, F., Frisch, B., and Ogier, J. (2012) Chemically detachable polyelectrolyte multilayer platform for cell sheet engineering. Chem. Mater. 24, 930-937.
- Pierrat, P., Creusat, G., Laverny, G., Pons, F., Zuber, G., and Lebeau, L. (2012) A cationic phospholipiddetergent conjugate as a new efficient carrier for siRNA delivery. Chem.-Eur. J. 18, 3835-3839.
- Creusat, G., Thomann, J.S., Maglott, A., Pons, B., Dontenwill, M., Guerin, E., Frisch, B., and Zuber, G. (2012) Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo. J. Control. Release 157, 418-426.
- Chardon, E., Puleo, G. L., Dahm, G., Fournel, S., Guichard, G., and Bellemin-Laponnaz, S. (2012) Easy derivatisation of group 10 N-heterocyclic carbene complexes and in vitro evaluation of an anticancer oestradiol conjugate. ChemPlusChem 77, 1028-1038.