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Accueil du site > Équipes > Équipe "Chimie et Neurobiologie Moléculaire"

Publication de l’équipe

2016

  • Habermacher, C., Martz, A., Calimet, N., Lemoine, D., Peverini, L., Specht, A., Cecchini, M., and Grutter, T. (2016) Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel. eLife 5, e11050.
  • Habermacher, C., Dunning, K., Chataigneau, T., Grutter, T., Molecular structure and function of P2X receptors. Neuropharmacology, (2016), 104:18-30.
  • Schmitt, J., Heitz, V., Sour, A., Bolze, F., Kessler, P., Flamigni, L., Ventura, B., Bonnet, C.S., and Toth, E. (2016) A theranostic agent combining a two-photon-absorbing photosensitizer for photodynamic therapy and a gadolinium(III) complex for MRI detection. Chem.-Eur. J. 22, 2775-86.
  • Tam, D.Y., Dai, Z. ; Chan, M.S., Liu, L. S., Cheung, M.C., Bolze, F., Tin, C., and Lo, P.K., (2016) A reversible DNA logic gate platform operated by one- and two-photon excitations. Angew. Chem. Int. Ed. Engl. 55, 164-8.
  • Piant, S., Specht, A., Zemelman, B., Losonczy, A., and Bolze, F. (2016) Two-photon sensitive photolabile protecting groups : From molecular engineering to nanostructuration. Mol. Cryst. Liquid Cryst. 627, 1-10.
  • Piant, S., Bolze, F., and Specht, A., (2016) Two-photon uncaging, from neuroscience to materials. Opt. Mater. Express, 6(5), 1679−1691.
  • Fichte, M. AH., Weyel, X. MM., Junek, S., Schäfer, F., Herbivo, C., Goeldner, M., Specht , A., Wachtveitl, J., Heckel, A., (2016) Three−Dimensional Control of DNA Hybridization by Orthogonal Two−Color Two−Photon Uncaging. Angew. Chem. Int. Ed. , 55(31), 8948−8952.

2015

  • Dai, Z., Tam, D. Y., Xu, H., Chan, M. S., Liu, L. S., Bolze, F., Sun, X. H., Lo, P. K., Conformational Change of Self-Assembled DNA Nanotubes Induced by Two-Photon Excitation. Small (2015), 11 (33), 4090-4096.
  • Guo, L., Chan, M. S., Xu, D., Tam, D. Y., Bolze, F., Lo, P. K., Wong, M. S., Indole-based Cyanine as a Nuclear RNA-Selective Two-Photon Fluorescent Probe for Live Cell Imaging., ACS chemical biology (2015), 10 (5), 1171-1175.
  • Chang, Y., Michelin, C., Bucher, L., Desbois, N., Gros, C. P., Piant, S., Bolze, F., Fang, Y., Jiang, X., Kadish, K. M., Synthesis and Characterization of Carbazole-Linked Porphyrin Tweezers., Chemistry – A European Journal 2015, 21 (34), 12018-12025.
  • Kellenberger, S., Grutter, T., Architectural and Functional Similarities between Trimeric ATP-Gated P2X Receptors and Acid-Sensing Ion Channels., J. Mol. Biol., (2015), 427, (1), 54–66.
  • Schmitt, J., Heitz, V., Sour, A., Bolze, F., Ftouni, H., Nicoud, J.-F., Flamigni, L., Ventura, B., Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy., Angew Chem Int Ed Engl (2015), 54 (1), 169-173.

2014

  • Garcia-Fernández, L., Specht, A., del Campo A., A Polyurethane-Based Positive Photoresist, Macromol. Rapid Commun. (2014), 35(20):1801-1807.
  • Garcia-Fernández, L., Herbivo, C., San Miguel Arranz, V., Warther, D., Donato, L., Specht, A., del Campo, A., Dual Photosensitive Polymers with Wavelength-Selective Photoresponse, Advanced Materials, 26, 5012–5017 (2014).

2013

  • Chataigneau, T., Lemoine, D., Grutter, T., Exploring the ATP-binding site of P2X receptors., Front Cell Neurosci. vol.7 art.273 (2013)
  • Lemoine, D., Habermacher, C., Martz, A., Méry, P-F., Bouquier, N., Diverchy, F., Taly, A., Rassendren, F., Specht, A., Grutter, T, Optical control of an ion channel gate. Proc Natl Acad Sci U S A. 110(51):20813-20818 (2013)
  • Herbivo, C., Omran, Z., Revol, J., Javot, H. and Specht, A., Synthesis and Characterization of Cell-Permeable Caged Phosphates that Can Be Photolyzed by Visible Light or 800 nm Two-Photon Photolysis. ChemBioChem 14(17) 2271-2283 (2013)
  • Ftouni, H. ; Bolze, F. ; de Rocquigny, H. ; Nicoud, J-F., Functionalized Two-Photon Absorbing Diketopyrrolopyrrole-Based Fluorophores for Living Cells Fluorescent Microscopy. Bioconjugate Chemistry (6), 942-950 (2013).
  • Anton, N. ; Atzenhoffer, M. ; Daubeuf, F. ; Li, X. ; Schini-Kerth, V.B. ; Delmotte, B. ; Vandamme, T.F. ; Chataigneau, T., Do iodinated nano-emulsions designed for preclinical vascular imaging alter the vascular reactivity in rat aorta ? International Journal of Pharmaceutics, 454(1) 143–148 (2013).
  • Specht, A. ; Bolze, F. ; Nicoud, J. F. ; Goeldner, M., Characterization of one- and two-photon photochemical uncaging efficiency. Methods Mol Biol 995, 79-87 (2013).
  • Jiang, R. ; Taly, A. ; Grutter, T., Moving through the gate in ATP-activated P2X receptors. Trends in biochemical sciences 38 (1), 20-9 (2013).

2012

  • Donato, L. ; Mourot, A. ; Davenport, C. M. ; Herbivo, C. ; Warther, D. ; Leonard, J. ; Bolze, F. ; Nicoud, J. F. ; Kramer, R. H. ; Goeldner, M. ; Specht, A., Water-soluble, donor-acceptor biphenyl derivatives in the 2-(o-nitrophenyl)propyl series : highly efficient two-photon uncaging of the neurotransmitter gamma-aminobutyric acid at lambda = 800 nm. Angew Chem Int Ed Engl 51 (8), 1840-3 (2012).
  • Jiang, R. ; Taly, A. ; Lemoine, D. ; Martz, A. ; Cunrath, O. ; Grutter, T., Tightening of the ATP-binding sites induces the opening of P2X receptor channels. The EMBO journal, 31 (9), 2134-43 (2012).
  • Jiang, R. ; Taly, A. ; Lemoine, D. ; Martz, A. ; Specht, A. ; Grutter, T., Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor. Channels (Austin), 6 (5), 398-402 (2012).
  • Lemoine, D. ; Jiang, R. ; Taly, A. ; Chataigneau, T. ; Specht, A. ; Grutter, T., Ligand-Gated Ion Channels : New Insights into Neurological Disorders and Ligand Recognition. Chemical reviews, 112 (12), 6285–6318 (2012).
  • Lorinczi, E. ; Bhargava, Y. ; Marino, S. F. ; Taly, A. ; Kaczmarek-Hajek, K. ; Barrantes-Freer, A. ; Dutertre, S. ; Grutter, T. ; Rettinger, J. ; Nicke, A., Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor. Proceedings of the National Academy of Sciences of the United States of America 109 (28), 11396-401 (2012).
  • Specht, A. ; Bolze, F. ; Donato, L. ; Herbivo, C. ; Charon, S. ; Warther, D. ; Gug, S. ; Nicoud, J. F. ; Goeldner, M., The donor-acceptor biphenyl platform : a versatile chromophore for the engineering of highly efficient two-photon sensitive photoremovable protecting groups. Photochemical & photobiological sciences 11 (3), 578-86 (2012).

2011

  • Jiang, R. ; Lemoine, D. ; Martz, A. ; Taly, A. ; Gonin, S. ; Prado de Carvalho, L. ; Specht, A. ; Grutter, T., Agonist trapped in ATP-binding sites of the P2X2 receptor. Proceedings of the National Academy of Sciences of the United States of America 108 (22), 9066-71 (2011).
  • Jiang, R. ; Miyamoto, A. ; Martz, A. ; Specht, A. ; Ishibashi, H. ; Kueny-Stotz, M. ; Chassaing, S. ; Brouillard, R. ; de Carvalho, L. P. ; Goeldner, M. ; Nabekura, J. ; Nielsen, M. ; Grutter, T., Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABA(A) receptors in vitro. British journal of pharmacology 162 (6), 1326-39 (2011).
  • Malmerberg, E. ; Omran, Z. ; Hub, J. S. ; Li, X. ; Katona, G. ; Westenhoff, S. ; Johansson, L. C. ; Andersson, M. ; Cammarata, M. ; Wulff, M. ; van der Spoel, D. ; Davidsson, J. ; Specht, A. ; Neutze, R., Time-resolved WAXS reveals accelerated conformational changes in iodoretinal-substituted proteorhodopsin. Biophysical journal 101 (6), 1345-53 (2011).
  • Nasiripourdori, A. ; Taly, V. ; Grutter, T. ; Taly, A., From toxins targeting ligand gated ion channels to therapeutic molecules. Toxins 3 (3), 260-93 (2011).
  • Puliti, D. ; Warther, D. ; Orange, C. ; Specht, A. ; Goeldner, M., Small photoactivatable molecules for controlled fluorescence activation in living cells. Bioorganic & medicinal chemistry 19 (3), 1023-9 (2011).

2010

  • Warther, D. ; Bolze, F. ; Leonard, J. ; Gug, S. ; Specht, A. ; Puliti, D. ; Sun, X. H. ; Kessler, P. ; Lutz, Y. ; Vonesch, J. L. ; Winsor, B. ; Nicoud, J. F. ; Goeldner, M., Live-cell one- and two-photon uncaging of a far-red emitting acridinone fluorophore. Journal of the American Chemical Society 132 (8), 2585-90 (2010).
  • Warther, D. ; Gug, S. ; Specht, A. ; Bolze, F. ; Nicoud, J. F. ; Mourot, A. ; Goeldner, M., Two-photon uncaging : New prospects in neuroscience and cellular biology. Bioorganic & medicinal chemistry 18 (22), 7753-8 (2010).
  • Jiang, R. ; Martz, A. ; Gonin, S. ; Taly, A. ; de Carvalho, L. P. ; Grutter, T., A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptor. The Journal of biological chemistry 285 (21), 15805-15 (2010).
  • Bolze, F ; Niehl, A. ; Heinlein, M. ; Mjdasiri, N. ; Rehspringer, J-L. ; Schaeffer, N. ; Didier, P. ; Arntz, Y. ; Mély, Y. ; Gug, S. ; Specht, A. ; Goeldner M. ; Nicoud. J-F. , Two-photon excitation in life sciences : From observation to action. Non Linear Optics Quantum Optics 40 (1−4), 253−265 (2010).

2009

  • Specht, A. ; Bolze, F. ; Omran, Z. ; Nicoud, J. F. ; Goeldner, M., Photochemical tools to study dynamic biological processes. HFSP journal 2009, 3 (4), 255-64.
  • Specht, A. ; Loudwig, S. ; Peng L. ; Goeldner, M., Complexing photolabile cholinergic ligands with synthetic and biological receptors : A dynamic survey. J. Incl. Phenom. Macrocycl. Chem. 65, 157-163 (2009).
  • S. Gug, S. ; Bolze, F. ; Bourgogne, C. ; Specht, A. ; Goeldner, M. ; Nicoud, J-F., A protecting group for two-photon uncaging. Synfacts 2009, 2, 155.
  • Omran, Z. ; Specht, A., Synthesis and photochemical properties of new photo-cleavable crosslinkers for the triggering of biological responses. Tetrahedron Lett. 50, 2434_2436 (2009).
  • Omran, Z. ; Specht, A., Short−length dimethoxynitrophenyl photo−cleavable crosslinkers,synthesis and photolysis. Journal of Photochemistry and Photobiology A : Chemistry 208, 125–130 (2009).

2008

  • Faham, S. ; Watanabe, A. ; Besserer, G. M. ; Cascio, D. ; Specht, A. ; Hirayama, B. A. ; Wright, E. M. ; Abramson, J., The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science 321 (5890), 810-4 (2008).
  • Guerlet, G. ; Taly, A. ; Prado de Carvalho, L. ; Martz, A. ; Jiang, R. ; Specht, A. ; Le Novere, N. ; Grutter, T., Comparative models of P2X2 receptor support inter-subunit ATP-binding sites. Biochemical and biophysical research communications 375 (3), 405-9 (2008).
  • Gug, S. ; Bolze, F. ; Specht, A. ; Bourgogne, C. ; Goeldner, M. ; Nicoud, J. F., Molecular engineering of photoremovable protecting groups for two-photon uncaging. Angew Chem Int Ed Engl 47 (49), 9525-9 (2008).
  • Gug, S. ; Charon, S. ; Specht, A. ; Alarcon, K. ; Ogden, D. ; Zietz, B. ; Leonard, J. ; Haacke, S. ; Bolze, F. ; Nicoud, J. F. ; Goeldner, M., Photolabile glutamate protecting group with high one- and two-photon uncaging efficiencies. Chembiochem : a European journal of chemical biology 9 (8), 1303-7 (2008).
  • Orange, C. ; Specht, A. ; Puliti, D. ; Sakr, E. ; Furuta, T. ; Winsor, B. ; Goeldner, M., Synthesis and photochemical properties of a light-activated fluorophore to label His-tagged proteins. Chem Commun (Camb) (10), 1217-9 (2008).
  • Petersen, S. ; Alonso, J. M. ; Specht, A. ; Duodu, P. ; Goeldner, M. ; del Campo, A., Phototriggering of cell adhesion by caged cyclic RGD peptides. Angew Chem Int Ed Engl 47 (17), 3192-5 (2008).