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Publication de l’équipe


1. Parisi, O. ; Scrivano, L. ; Candamano, S. ; Ruffo, M. ; Vattimo, A. ; Spanedda, M. ; Puoci, F., Molecularly Imprinted Microrods via Mesophase Polymerization. Molecules 2018, 23 (1). Response in Vivo ? Annals of the rheumatic diseases 2018, 77, A13-A13.

2. Kporou Kouassi, E. ; Ouattara, S. ; Seguin, C. ; Fournel, S. ; Frisch, B., Etude De Quelques Proprietes Biologiques De Ocimum Gratissimum L., Une Lamiaceae Recoltee A Daloa (Côte d’Ivoire). European Scientific Journal 2018, 14 (3), 477-493.

3. Chekkat, N. ; Lombardo, C. M. ; Lechner, M.-C. ; Seguin, C. ; Dufour, F. ; Frisch, B. ; Micheau, O. ; Guichard, G. ; Altschuh, D. ; Fournel, S., Relationship between the agonist activity of synthetic ligands of TRAIL-R2 and their cell surface binding modes. Oncotarget 2018, 9, 15566-15578.


1. Zahouani, S. ; Hurman, L. ; De Giorgi, M. ; Vigier-Carriere, C. ; Boulmedais, F. ; Senger, B. ; Frisch, B. ; Schaaf, P. ; Lavalle, P. ; Jierry, L., Step-by-step build-up of covalent poly(ethylene oxide) nanogel films. Nanoscale 2017, 9 (46), 18379-18391.

2. Zaet, A. ; Dartevelle, P. ; Daouad, F. ; Ehlinger, C. ; Quiles, F. ; Francius, G. ; Boehler, C. ; Bergthold, C. ; Frisch, B. ; Prevost, G. ; Lavalle, P. ; Schneider, F. ; Haikel, Y. ; Metz-Boutigue, M. H. ; Marban, C., D-Cateslytin, a new antimicrobial peptide with therapeutic potential. Sci Rep 2017, 7 (1), 15199.

3. Spanedda, M. V. ; De Giorgi, M. ; Hassane, F. S. ; Schuber, F. ; Bourel-Bonnet, L. ; Frisch, B., Coupling of Ligands to the Liposome Surface by Click Chemistry. Methods Mol Biol 2017, 1522, 93-106.

4. Smulski, C. R. ; Decossas, M. ; Chekkat, N. ; Beyrath, J. ; Willen, L. ; Guichard, G. ; Lorenzetti, R. ; Rizzi, M. ; Eibel, H. ; Schneider, P. ; Fournel, S., Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling. Cell Death Dis 2017, 8 (2), e2601.

5. Saliba, H. ; Heurtault, B. ; Bouharoun-Tayoun, H. ; Flacher, V. ; Frisch, B. ; Fournel, S. ; Chamat, S., Enhancing tumor specific immune responses by transcutaneous vaccination. Expert Rev Vaccines 2017.

6. Phoeung, T. ; Spanedda, M. V. ; Roger, E. ; Heurtault, B. ; Foumel, S. ; Reisch, A. ; Mutschler, A. ; Perrin-Schmitt, F. ; Hemmerle, J. ; Collin, D. ; Rawiso, M. ; Boulmedais, F. ; Schaaf, P. ; Lavalle, P. ; Frisch, B., Alginate/Chitosan Compact Polyelectrolyte Complexes : A Cell and Bacterial Repellent Material. Chem Mater 2017, 29 (24), 10418-10425.

7. Nicolas-Boluda, A. ; Silva, A. K. A. ; Fournel, S. ; Gazeau, F., Physical oncology : New targets for nanomedicine. Biomaterials 2017, 150, 87-99.

8. Macho-Fernandez, E. ; Chekkat, N. ; Ehret, C. ; Thomann, J. S. ; De Giorgi, M. ; Spanedda, M. V. ; Bourel-Bonnet, L. ; Betbeder, D. ; Heurtault, B. ; Faveeuw, C. ; Fournel, S. ; Frisch, B. ; Trottein, F., Solubilization of alpha-galactosylceramide in aqueous medium : Impact on Natural Killer T cell activation and antitumor responses. Int J Pharm 2017, 530 (1-2), 354-363.

9. Gossart, J. B. ; Pascal, E. ; Meyer, F. ; Heuillard, E. ; Goncalves, M. ; Gosse, F. ; Robinet, E. ; Frisch, B. ; Seguin, C. ; Zuber, G., Performance of Pyridylthiourea-Polyethylenimine Polyplex for siRNA-Mediated Liver Cancer Therapy in Cell Monolayer, Spheroid, and Tumor Xenograft Models. Glob Chall 2017, 1 (4).

10. Fogha, J. ; Marekha, B. ; De Giorgi, M. ; Voisin-Chiret, A. S. ; Rault, S. ; Bureau, R. ; Sopkova-de Oliveira Santos, J., Toward Understanding Mcl-1 Promiscuous and Specific Binding Mode. J Chem Inf Model 2017, 57 (11), 2885-2895.

11. Mariotte, A. ; Zhang, Z. ; de Cauwer, A. ; Frisch, B. ; Bahram, S. ; Ricci, R. ; Georgel, P., Which Place for the Nlrp3 Inflammasome in the Msu Crystal-Induced Inflammatory


Kakhi, Z., Frisch, B., Heurtault, B., and Pons, F. (2016) Liposomal constructs for antitumoral vaccination by the nasal route. In Press Biochimie.

Fend, L., Remy-Ziller, C., Foloppe, J., Kempf, J., Cochin, S., Barraud, L., Accart, N., Erbs, P., Fournel, S., and Preville, X. (2016) Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor microenvironment. Oncoimmunology 5, e1080414 1-11

Chekkat, N., Dahm, G., Chardon, E., Wantz, M., Sitz, J., Decossas, M., Lambert, O., Frisch, B., Rubbiani, R., Gasser, G., Guichard, G., Fournel, S., and Bellemin-Laponnaz, S. (2016) N-Heterocyclic Carbene-Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy. Bioconjug Chem 27, 1942-1948

Beyrath, J., Chekkat, N., Smulski, C. R., Lombardo, C. M., Lechner, M. C., Seguin, C., Decossas, M., Spanedda, M. V., Frisch, B., Guichard, G., and Fournel, S. (2016) Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels. Oncotarget 7, 64942-64956

Barthelemy, A., Ivanov, S., Hassane, M., Fontaine, J., Heurtault, B., Frisch, B., Sirard, J. C., Faveeuw, C., Paget, C., and Trottein, F. (2016) Exogenous activation of invariant Natural Killer T cells by α-galactosylceramide reduces pneumococcal outgrowth and dissemination post-influenza In Press MBIO.

Pierrat, P., Casset, A., Kereselidze, D., Lux, M., Pons, F., and Lebeau, L. (2016) DOPC-Detergent Conjugates : Fusogenic Carriers for Improved In Vitro and In Vivo Gene Delivery. In Press Macromolecular Bioscience


Pierrat, P. ; Wang, R. ; Kereselidze, D. ; Lux, M. ; Didier, P. ; Kichler, A. ; Pons, F. ; Lebeau, L. Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers. Biomaterials 2015, 51, 290.

Salome, C., Spanedda, M. V., Hilbold, B., Berner, E., Heurtault, B., Fournel, S., Frisch, B., and Bourel-Bonnet, L. Smart tools and orthogonal click-like reactions onto small unilamellar vesicles. Chem Phys Lipids. 2015, 188, 27-36

Rios, C. ; Longo, J. ; Zahouani, S. ; Garnier, T. ; Vogt, C. ; Reisch, A. ; Senger, B. ; Boulmedais, F. ; Hemmerle, J. ; Benmlih, K. ; Frisch, B. ; Schaaf, P. ; Jierry, L. ; Lavalle, P., A new biomimetic route to engineer enzymatically active mechano-responsive materials. Chem Commun (Camb) 2015, 51, 5622.

Pulka-Ziach, K. ; Pavet, V. ; Chekkat, N. ; Estieu-Gionnet, K. ; Rohac, R. ; Lechner, MC. ; Smulski, CR. ; Zeder-Lutz, G. ; Altschuh, D. ; Gronemeyer, H. ; Fournel, S. ; Odaert, B. ; Guichard, G. Thioether Analogues of Disulfide-bridged Cyclic Peptides Targeting Death Receptor 5 : Conformational Analysis, Dimerization and Consequences for Receptor Activation. Chembiochem. 2015, 16, 293-30.


Ronzani, C. ; Casset, A. ; Pons, F., Exposure to multi-walled carbon nanotubes results in aggravation of airway inflammation and remodeling and in increased production of epithelium-derived innate cytokines in a mouse model of asthma. Arch Toxicol 2014, 88, 489.

Reisch, A. ; Roger, E. ; Phoeung, T. ; Antheaume, C. ; Orthlieb, C. ; Boulmedais, F. ; Lavalle, P. ; Schlenoff, J. B. ; Frisch, B. ; Schaaf, P., On the Benefits of Rubbing Salt in the Cut : Self-Healing of Saloplastic PAA/PAH Compact Polyelectrolyte Complexes. Advanced materials 2014, 26, 2547.

Pinel, S. ; Aman, E. ; Erblang, F. ; Dietrich, J. ; Frisch, B. ; Sirman, J. ; Kichler, A. ; Sibler, A. P. ; Dontenwill, M. ; Schaffner, F. ; Zuber, G., Quantitative measurement of delivery and gene silencing activities of siRNA polyplexes containing pyridylthiourea-grafted polyethylenimines. Journal of controlled release : official journal of the Controlled Release Society 2014, 182C, 1.

Macho-Fernandez, E. ; Cruz, L. J. ; Ghinnagow, R. ; Fontaine, J. ; Bialecki, E. ; Frisch, B. ; Trottein, F. ; Faveeuw, C., Targeted delivery of alpha-galactosylceramide to CD8alpha+ dendritic cells optimizes type I NKT cell-based antitumor responses. J Immunol 2014, 193, 961.

Heurtault, B. ; Reix, N. ; Meyer, N. ; Gasser, F. ; Wendling, M. J. ; Ratomponirina, C. ; Jeandidier, N. ; Sapin, R. ; Agin, A., Extensive study of human insulin immunoassays : promises and pitfalls for insulin analogue detection and quantification. Clin Chem Lab Med 2014, 52, 355.

Fend, L. ; Gatard-Scheikl, T. ; Kintz, J. ; Gantzer, M. ; Schaedler, E. ; Rittner, K. ; Cochin, S. ; Fournel, S. ; Preville, X., Intravenous Injection of MVA Virus Targets CD8+ Lymphocytes to Tumors to Control Tumor Growth upon Combinatorial Treatment with a TLR9 Agonist. Cancer Immunol Res 2014

Attia, M. F. ; Anton, N. ; Chiper, M. ; Akasov, R. ; Anton, H. ; Messaddeq, N. ; Fournel, S. ; Klymchenko, A. S. ; Mely, Y. ; Vandamme, T. F., Biodistribution of x-ray iodinated contrast agent in nano-emulsions is controlled by the chemical nature of the oily core. ACS nano 2014, 8, 10537.


Bacharouche, J., Badique, F., Fahs, A., Spanedda, M. V., Geissler, A., Malval, J. P., Vallat, M. F., Anselme, K., Francius, G., Frisch, B., Hemmerle, J., Schaaf, P. and Roucoules, V. Biomimetic cryptic site surfaces for reversible chemo- and cyto-mechanoresponsive substrates. ACS Nano 2013, 7, 3457-65.

Barnig, C., Purohit, A., Casset, A., Sohy, C., Lieutier-Colas, F., Sauleau, E. and de Blay, F. Nonallergic Airway Hyperresponsiveness and Allergen-Specific IgE Levels Are the Main Determinants of the Early and Late Asthmatic Response to Allergen. Journal of Investigational Allergology and Clinical Immunology 2013, 23, 267-274.

Barnig, C., Reboux, G., Roussel, S., Casset, A., Sohy, C., Dalphin, J. C. and de Blay, F. Indoor dust and air concentrations of endotoxin in urban and rural environments. Lett Appl Microbiol 2013, 56, 161-7.

Bohren, Y., Tessier, L. H., Megat, S., Petitjean, H., Hugel, S., Daniel, D., Kremer, M., Fournel, S., Hein, L., Schlichter, R., Freund-Mercier, M. J., Yalcin, I. and Barrot, M. Antidepressants suppress neuropathic pain by a peripheral beta2-adrenoceptor mediated anti-TNFalpha mechanism. Neurobiology of disease 2013, 60, 39-50.

Casset, A., Valenta, R. and Vrtala, S. Allergen content and in vivo allergenic activity of house dust mite extracts. Int Arch Allergy Immunol 2013, 161, 287-8.

Devarasu, T., Saad, R., Ouadi, A., Frisch, B., Robinet, E., Laquerriere, P., Voegel, J. C., Baumert, T., Ogier, J. and Meyer, F. Potent calcium phosphate nanoparticle surface coating for in vitro and in vivo siRNA delivery : a step toward multifunctional nanovectors. Journal of Materials Chemistry B 2013, 1, 4692-4700.

Fend, L., Accart, N., Kintz, J., Cochin, S., Reymann, C., Le Pogam, F., Marchand, J. B., Menguy, T., Slos, P., Rooke, R., Fournel, S., Bonnefoy, J. Y., Preville, X. and Haegel, H. Therapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts. PloS one 2013, 8, e73310.

Gentine, P., Bourel-Bonnet, L. and Frisch, B. Modified and derived ethanol injection toward liposomes : development of the process. J Liposome Res 2013, 23, 11-9.

Grandemange, E., Fournel, S. and Woehrle, F. Efficacy and safety of cimicoxib in the control of perioperative pain in dogs. The Journal of small animal practice 2013, 54, 304-12.

Kastner, P. E., Le Calve, S., Zheng, W. Y., Casset, A. and Pons, F. A dynamic system for single and repeated exposure of airway epithelial cells to gaseous pollutants. Toxicology in Vitro 2013, 27, 632-640.

Lamanna, G., Smulski, C. R., Chekkat, N., Estieu-Gionnet, K., Guichard, G., Fournel, S. and Bianco, A. Multimerization of an apoptogenic TRAIL-mimicking peptide by using adamantane-based dendrons. Chemistry 2013, 19, 1762-8.

Laverny, G., Casset, A., Purohit, A., Schaeffer, E., Spiegelhalter, C., de Blay, F. and Pons, F. Immunomodulatory properties of multi-walled carbon nanotubes in peripheral blood mononuclear cells from healthy subjects and allergic patients. Toxicol Lett 2013, 217, 91-101.

Philippe, L., Alsaleh, G., Pichot, A., Ostermann, E., Zuber, G., Frisch, B., Sibilia, J., Pfeffer, S., Bahram, S., Wachsmann, D. and Georgel, P. MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes. Ann Rheum Dis 2013, 72, 1071-9.

Pierrat, P., Kereselidze, D., Wehrung, P., Zuber, G., Pons, F. and Lebeau, L. Bioresponsive Deciduous-Charge Amphiphiles for Liposomal Delivery of DNA and siRNA. Pharmaceutical Research 2013, 30, 1362-1379.

Pierrat, P., Laverny, G., Creusat, G., Wehrung, P., Strub, J. M., VanDorsselaer, A., Pons, F., Zuber, G. and Lebeau, L. Phospholipid-Detergent Conjugates as Novel Tools for siRNA Delivery. Chemistry-a European Journal 2013, 19, 2344-2355.

Reisch, A., Tirado, P., Roger, E., Boulmedais, F., Collin, D., Voegel, J.-C., Frisch, B., Schaaf, P. and Schlenoff, J. Compact Saloplastic Poly(Acrylic Acid)/Poly(Allylamine) Complexes : Kinetic Control Over Composition, Microstructure, and Mechanical Properties. Adv. Funct. Mater. 2013, 23, 673-682.

Reix, N., Massart, C., d’Herbomez, M., Gasser, F., Heurtault, B. and Agin, A. Thyroid-stimulating hormone and free thyroxine on the ADVIA Centaur immunoassay system : a multicenter assessment of analytical performance. Clinical biochemistry 2013, 46, 1305-8.

Reix, N., Sigrist, S., Heurtault, B., Agin, A., Moreau, F., Pinget, M. and Jeandidier, N. Glycemic management of diabetes by insulin therapy. Minerva endocrinologica 2013, 38, 29-46.

Rydzek, G., Garnier, T., Schaaf, P., Voegel, J. C., Senger, B., Frisch, B., Haikel, Y., Petit, C., Schlatter, G., Jierry, L. and Boulmedais, F. Self-construction of supramolecular polyrotaxane films by an electrotriggered morphogen-driven process. Langmuir 2013.

Smulski, C. R., Beyrath, J., Decossas, M., Chekkat, N., Wolff, P., Estieu-Gionnet, K., Guichard, G., Speiser, D., Schneider, P. and Fournel, S. Cysteine-rich domain 1 of CD40 mediates receptor self-assembly. The Journal of biological chemistry 2013, 288, 10914-22.

Tirado, P., Reisch, A., Roger, E., Boulmedais, F., Jierry, L., Lavalle, P., Voegel, J.-C., Schaaf, P., Schlenoff, J. and Frisch, B. Catalytic Saloplastics : Alkaline Phosphatase Immobilized and Stabilized in Compacted Polyelectrolyte Complexes. Adv. Funct. Mater. 2013, 23, 4785-4792.

Weghofer, M., Grote, M., Resch, Y., Casset, A., Kneidinger, M., Kopec, J., Thomas, W. R., Fernandez-Caldas, E., Kabesch, M., Ferrara, R., Mari, A., Purohit, A., Pauli, G., Horak, F., Keller, W., Valent, P., Valenta, R. and Vrtala, S. Identification of Der p 23, a Peritrophin-like Protein, as a New Major Dermatophagoides pteronyssinus Allergen Associated with the Peritrophic Matrix of Mite Fecal Pellets. Journal of Immunology 2013, 190, 3059-3067.


Barnig, C. and Casset, A. Respiratory allergens and asthma exacerbation. Revue Des Maladies Respiratoires 2012, 29, 810-819.

Becker, J., Delayre-Orthez, C., Frossard, N. and Pons, F. The peroxisome proliferator-activated receptor alpha agonist fenofibrate decreases airway reactivity to methacholine and increases endothelial nitric oxide synthase phosphorylation in mouse lung. Fundamental & Clinical Pharmacology 2012, 26, 340-346.

RCL49 Casset, A., Mari, A., Purohit, A., Resch, Y., Weghofer, M., Ferrara, R., Thomas, W. R., Alessandri, C., Chen, K. W., de Blay, F., Valenta, R. and Vrtala, S. Varying Allergen Composition and Content Affects the in vivo Allergenic Activity of Commercial Dermatophagoides pteronyssinus Extracts. International Archives of Allergy and Immunology 2012, 159, 253-262.

Chassepot, A., Gao, L. C., Nguyen, I., Dochter, A., Fioretti, F., Menu, P., Kerdjoudj, H., Baehr, C., Schaaf, P., Voegel, J. C., Boulmedais, F., Frisch, B. and Ogiert, J. Chemically Detachable Polyelectrolyte Multilayer Platform for Cell Sheet Engineering. Chemistry of Materials 2012, 24, 930-937.

Creusat, G., Thomann, J. S., Maglott, A., Pons, B., Dontenwill, M., Guerin, E., Frisch, B. and Zuber, G. Pyridylthiourea-grafted polyethylenimine offers an effective assistance to siRNA-mediated gene silencing in vitro and in vivo. Journal of Controlled Release 2012, 157, 418-426.

Davila, J., Chassepot, A., Longo, J., Boulmedais, F., Reisch, A., Frisch, B., Meyer, F., Voegel, J. C., Mesini, P. J., Senger, B., Metz-Boutigue, M. H., Hemmerle, J., Lavalle, P., Schaaf, P. and Jierry, L. Cyto-mechanoresponsive Polyelectrolyte Multilayer Films. Journal of the American Chemical Society 2012, 134, 83-86.

Fernandez, E. M., Chang, J., Fontaine, J., Bialecki, E., Rodriguez, F., Werkmeister, E., Krieger, V., Ehret, C., Heurtault, B., Fournel, S., Frisch, B., Betbeder, D., Faveeuw, C. and Trottein, F. Activation of invariant Natural Killer T lymphocytes in response to the alpha-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nanoparticles and microparticles. International Journal of Pharmaceutics 2012, 423, 45-54.

Gentine, P., Bubel, A., Crucifix, C., Bourel-Bonnet, L. and Frisch, B. Manufacture of liposomes by isopropanol injection : characterization of the method. Journal of Liposome Research 2012, 22, 18-30.

Ivanov, S., Fontaine, J., Paget, C., Fernandez, E. M., Van Maele, L., Renneson, J., Maillet, I., Wolf, N. M., Rial, A., Leger, H., Ryffel, B., Frisch, B., Chabalgoity, J. A., Sirard, J. C., Benecke, A., Faveeuw, C. and Trottein, F. Key Role for Respiratory CD103(+) Dendritic Cells, IFN-gamma, and IL-17 in Protection Against Streptococcus pneumoniae Infection in Response to alpha-Galactosylceramide. Journal of Infectious Diseases 2012, 206, 723-734.

Macho Fernandez, E., Chang, J., Fontaine, J., Bialecki, E., Rodriguez, F., Werkmeister, E., Krieger, V., Ehret, C., Heurtault, B., Fournel, S., Frisch, B., Betbeder, D., Faveeuw, C. and Trottein, F. Activation of invariant Natural Killer T lymphocytes in response to the alpha-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nanoparticles and microparticles. International journal of pharmaceutics 2012, 423, 45-54.

Pierrat, P., Creusat, G., Laverny, G., Pons, F., Zuber, G. and Lebeau, L. A Cationic Phospholipid-Detergent Conjugate as a New Efficient Carrier for siRNA Delivery. Chemistry-a European Journal 2012, 18, 3835-3839.

Reix, N., Massart, C., Gasser, F., Heurtault, B. and Agin, A. Should functional sensitivity of a new thyroid stimulating hormone immunoassay be monitored routinely ? The ADVIA Centaur TSH3-UL assay experience. Clinical biochemistry 2012, 45, 1260-2.

Roger, E., Kalscheuer, S., Kirtane, A., Guru, B. R., Grill, A. E., Whittum-Hudson, J. and Panyam, J. Folic Acid Functionalized Nanoparticles for Enhanced Oral Drug Delivery. Molecular Pharmaceutics 2012, 9, 2103-2110.

Ronzani, C., Spiegelhalter, C., Vonesch, J. L., Lebeau, L. and Pons, F. Lung deposition and toxicological responses evoked by multi-walled carbon nanotubes dispersed in a synthetic lung surfactant in the mouse. Archives of Toxicology 2012, 86, 137-149.

Rydzek, G., Parat, A., Polavarapu, P., Baehr, C., Voegel, J. C., Hemmerle, J., Senger, B., Frisch, B., Schaaf, P., Jierry, L. and Boulmedais, F. One-pot morphogen driven self-constructing films based on non-covalent host-guest interactions. Soft Matter 2012, 8, 446-453.

Rydzek, G., Polavarapu, P., Rios, C., Tisserant, J. N., Voegel, J. C., Senger, B., Lavalle, P., Frisch, B., Schaaf, P., Boulmedais, F. and Jierry, L. Morphogen-driven self-construction of covalent films built from polyelectrolytes and homobifunctional spacers : buildup and pH response. Soft Matter 2012, 8, 10336-10343.

Thomann, J. S., Monneaux, F., Creusat, G., Spanedda, M. V., Heurtault, B., Habermacher, C., Schuber, F., Bourel-Bonnet, L. and Frisch, B. Novel glycolipid TLR2 ligands of the type Pam2Cys-alpha-Gal : synthesis and biological properties. European journal of medicinal chemistry 2012, 51, 174-83.


Bialecki, E., Fernandez, E. M., Ivanov, S., Paget, C., Fontaine, J., Rodriguez, F., Lebeau, L., Ehret, C., Frisch, B., Trottein, F. and Faveeuw, C. Spleen-Resident CD4(+) and CD4(-) CD8 alpha(-) Dendritic Cell Subsets Differ in Their Ability to Prime Invariant Natural Killer T Lymphocytes. Plos One 2011, 6.

Boeglin, E., Smulski, C. R., Brun, S., Milosevic, S., Schneider, P. and Fournel, S. Toll-Like Receptor Agonists Synergize with CD40L to Induce Either Proliferation or Plasma Cell Differentiation of Mouse B Cells. Plos One 2011, 6.

Casset, A. and Braun, J. J. Relationships between indoor allergens, sensitization, and allergic asthma and rhinitis symptoms. Revue Francaise D Allergologie 2011, 51, 104-110.

Ferrara, R., Palazzo, P., Alessandri, C., Casset, A., Liso, M., Scala, E., Valenta, R., Vrtala, S. and Mari, A. Detection of Der p 1, Der p 2, Der f 1, Der f 2, and Der p 10 in commercial D. farinae and D. pteronyssinus extracts by single point highest inhibition achievable assay. Allergy 2011, 66, 322-322.

Greiner, V. J., Shvadchak, V., Fritz, J., Arntz, Y., Didier, P., Frisch, B., Boudier, C., Mely, Y. and de Rocquigny, H. Characterization of the mechanisms of HIV-1 Vpr(52-96) internalization in cells. Biochimie 2011, 93, 1647-1658.

Hilbold, B., Perrault, M., Ehret, C., Niu, S. L., Frisch, B., Pecheur, E. I. and Bourel-Bonnet, L. Benzophenone-containing fatty acids and their related photosensitive fluorescent new probes : Design, physico-chemical properties and preliminary functional investigations. Bioorganic & Medicinal Chemistry 2011, 19, 7464-7473.

Kastner, P. E., Casset, A. and Pons, F. Formaldehyde interferes with airway epithelium integrity and functions in a dose- and time-dependent manner. Toxicology Letters 2011, 200, 109-116.

Kastner, P. E., Le Calve, S., Casset, A., Zheng, W. and Pons, F. Exposure of airway epithelial cells in culture to a mixture of gaseous pollutants : Impact on cell integrity. Toxicology Letters 2011, 205, S123-S123.

Laverny, G., Casset, A., Purohit, A., de Blay, F. and Pons, F. Effects of Carbon Nanotubes on Cytokine Secretion by Peripheral Blood Mononuclear Cells from Healthy Subjects and Allergic Patients. Inflammation Research 2011, 60, 175-176.

Pons, F., Laverny, G., Purohit, A., De Blay, F. and Casset, A. Immunomodulatory properties of multi-walled carbon nanotubes in peripheral blood mononuclear cells. Toxicology Letters 2011, 205, S286-S287.

Roger, E., Lagarce, F. and Benoit, J. P. Development and characterization of a novel lipid nanocapsule formulation of Sn38 for oral administration. European Journal of Pharmaceutics and Biopharmaceutics 2011, 79, 181-188.

Ronzani, C., Casset, A. and Pons, F. Effect of multi-walled carbon nanotubes on lung inflammation and systemic immune response in murine asthma models. Toxicology Letters 2011, 205, S288-S288.

Rydzek, G., Jierry, L., Parat, A., Thomann, J. S., Voegel, J. C., Senger, B., Hemmerle, J., Ponche, A., Frisch, B., Schaaf, P. and Boulmedais, F. Electrochemically Triggered Assembly of Films : A One-Pot Morphogen-Driven Buildup. Angewandte Chemie-International Edition 2011, 50, 4374-4377.

Thomann, J. S., Heurtault, B., Weidner, S., Braye, M., Beyrath, J., Fournel, S., Schuber, F. and Frisch, B. Antitumor activity of liposomal ErbB2/HER2 epitope peptide-based vaccine constructs incorporating TLR agonists and mannose receptor targeting. Biomaterials 2011, 32, 4574-83.


Barnig, C., Purohit, A., Casset, A., Sohy, C., Lieutier-Colas, F., Meyer, P. and de Blay, F. Predictor factors for airway responsiveness during bronchial allergen challenge tests : role of allergen-specific IgE levels, cutaneous allergen sensitivity and non-specific airway hyperresponsiveness. Allergy 2010, 65, 20-20.

Bernsmann, F., Frisch, B., Ringwald, C. and Ball, V. Protein adsorption on dopamine-melanin films : Role of electrostatic interactions inferred from zeta-potential measurements versus chemisorption. Journal of Colloid and Interface Science 2010, 344, 54-60.

Casset, A. and Braun, J. J. Relationships between indoor allergens, sensitization, and allergic asthma and rhinitis symptoms. Revue Des Maladies Respiratoires 2010, 27, 913-920.

Claudon, P., Violette, A., Lamour, K., Decossas, M., Fournel, S., Heurtault, B., Godet, J., Mely, Y., Jamart-Gregoire, B., Averlant-Petit, M. C., Briand, J. P., Duportail, G., Monteil, H. and Guichard, G. Consequences of isostructural main-chain modifications for the design of antimicrobial foldamers : helical mimics of host-defense peptides based on a heterogeneous amide/urea backbone. Angewandte Chemie 2010, 49, 333-6.

El Haitami, A. E., Thomann, J. S., Jierry, L., Parat, A., Voegel, J. C., Schaaf, P., Senger, B., Boulmedais, F. and Frisch, B. Covalent Layer-by-Layer Assemblies of Polyelectrolytes and Homobifunctional Spacers. Langmuir 2010, 26, 12351-12357.

Frisch, B., Hassane, F. S. and Schuber, F. Conjugation of ligands to the surface of preformed liposomes by click chemistry. Methods Mol Biol 2010, 605, 267-77.

Geissler, A., Vallat, M. F., Fioux, P., Thomann, J. S., Frisch, B., Voegel, J. C., Hemmerle, J., Schaaf, P. and Roucoules, V. Multifunctional Stretchable Plasma Polymer Modified PDMS Interface for Mechanically Responsive Materials. Plasma Processes and Polymers 2010, 7, 64-77.

Gorska, K., Beyrath, J., Fournel, S., Guichard, G. and Winssinger, N. Ligand dimerization programmed by hybridization to study multimeric ligand-receptor interactions. Chemical communications 2010, 46, 7742-4.

Heurtault, B., Frisch, B. and Pons, F. Liposomes as delivery systems for nasal vaccination : strategies and outcomes. Expert opinion on drug delivery 2010, 7, 829-44.

Huynh, N. T., Roger, E., Lautram, N., Benoit, J. P. and Passirani, C. The rise and rise of stealth nanocarriers for cancer therapy : passive versus active targeting. Nanomedicine 2010, 5, 1415-1433.

Jierry, L., Ben Ameur, N., Thomann, J. S., Frisch, B., Gonthier, E., Voegel, J. C., Senger, B., Decher, G., Felix, O., Schaaf, P., Mesini, P. and Boulmedais, F. Influence of Cu(I)-Alkyne pi-Complex Charge on the Step-by-Step Film Buildup through Sharpless Click Reaction. Macromolecules 2010, 43, 3994-3997.

Klein, E., Ciobanu, M., Klein, J., Machi, V., Leborgne, C., Vandamme, T., Frisch, B., Pons, F., Kichler, A., Zuber, G. and Lebeau, L. "HFP" Fluorinated Cationic Lipids for Enhanced Lipoplex Stability and Gene Delivery. Bioconjugate Chemistry 2010, 21, 360-371.

Klein, E., Leborgne, C., Ciobanu, M., Klein, J., Frisch, B., Pons, F., Zuber, G., Scherman, D., Kichler, A. and Lebeau, L. Nucleic acid transfer with hemifluorinated polycationic lipids. Biomaterials 2010, 31, 4781-4788.

Mignet, N., Vandermeulen, G., Pembouong, G., Largeau, C., Thompson, B., Spanedda, M. V., Wasungu, L., Rols, M. P., Bessodes, M., Bureau, M. F., Preat, V. and Scherman, D. Cationic and anionic lipoplexes inhibit gene transfection by electroporation in vivo. Journal of Gene Medicine 2010, 12, 491-500.

Pavet, V., Beyrath, J., Pardin, C., Morizot, A., Lechner, M. C., Briand, J. P., Wendland, M., Maison, W., Fournel, S., Micheau, O., Guichard, G. and Gronemeyer, H. Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity. Cancer research 2010, 70, 1101-10.

Roger, E., Lagarce, F., Garcion, E. and Benoit, J. P. Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery. Nanomedicine 2010, 5, 287-306.

Roger, E., Lagarce, F., Garcion, E. and Benoit, J. P. Reciprocal competition between lipid nanocapsules and P-gp for paclitaxel transport across Caco-2 cells. European Journal of Pharmaceutical Sciences 2010, 40, 422-429.

Rydzek, G., Thomann, J. S., Ben Ameur, N., Jierry, L., Mesini, P., Ponche, A., Contal, C., El Haitami, A. E., Voegel, J. C., Senger, B., Schaaf, P., Frisch, B. and Boulmedais, F. Polymer Multilayer Films Obtained by Electrochemically Catalyzed Click Chemistry. Langmuir 2010, 26, 2816-2824.

Shaklee, P. M., Bourel-Bonnet, L., Dogterom, M. and Schmidt, T. Nonprocessive Motor Dynamics at the Microtubule Membrane Tube Interface. Biophysical Journal 2010, 98, 93-100.

Shaklee, P. M., Idema, T., Bourel-Bonnet, L., Dogterom, M. and Schmidt, T. Kinesin Recycling in Stationary Membrane Tubes. Biophysical Journal 2010, 99, 1835-1841.

Spanedda, M. V., Heurtault, B., Weidner, S., Baehr, C., Boeglin, E., Beyrath, J., Milosevic, S., Bourel-Bonnet, L., Fournel, S. and Frisch, B. Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway. Bioorganic & medicinal chemistry letters 2010, 20, 1869-72.


Barnig, C., Purohit, A., Casset, A., Sohy, C., Lieutier-Colas, F. and de Blay, F. Predictor Factors for Airway Responsiveness during Bronchial Allergen Challenge Tests : Role of Allergen-Specific IgE Levels, Cutaneous Allergen Sensitivity and Non-Specific Airway Hyperresponsiveness. Journal of Allergy and Clinical Immunology 2009, 123, S9-S9.

Brandhonneur, N., Chevanne, F., Vie, V., Frisch, B., Primault, R., Le Potier, M. F. and Le Corre, P. Specific and non-specific phagocytosis of ligand-grafted PLGA microspheres by macrophages. European Journal of Pharmaceutical Sciences 2009, 36, 474-485.

Guichard, G., Trouche, N., Wieckowski, S., Sun, W., Chaloin, O., Bianco, A., Hoebeke, J., Schneider, P. and Fournel, S. Rationally-designed multivalent architectures for mimicking homotrimers of CD40L, a member of the TNF superfamily. Advances in experimental medicine and biology 2009, 611, 355-7.

Guichard, G., Trouche, N., Wieckowski, S., Sun, W. M., Chaloin, O., Bianco, A., Hoebeke, J., Schneider, P. and Fournel, S. Rationally-designed Multivalent Architectures for Mimicking Homotrimers of CD40L, a Member of the TNF Superfamily. Journal 2009, 611, 355-357.

Hassane, F. S., Phalipon, A., Tanguy, M., Guerreiro, C., Belot, F., Frisch, B., Mulard, L. A. and Schuber, F. Rational design and immunogenicity of liposome-based diepitope constructs : Application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen. Vaccine 2009, 27, 5419-5426.

Heurtault, B., Gentine, P., Thomann, J. S., Baehr, C., Frisch, B. and Pons, F. Design of a liposomal candidate vaccine against Pseudomonas aeruginosa and its evaluation in triggering systemic and lung mucosal immunity. Pharmaceutical research 2009, 26, 276-85.

Hureaux, J., Lagarce, F., Gagnadoux, F., Clavreul, A., Roger, E., Benoit, J. P. and Urban, T. Lipid nanocapsules : an original drug nanocarrier for lung cancer therapy. Journal of Thoracic Oncology 2009, 4, S623-S623.

Hureaux, J., Lagarce, F., Gagnadoux, F., Vecellio, L., Clavreul, A., Roger, E., Kempf, M., Racineux, J. L., Diot, P., Benoit, J. P. and Urban, T. Lipid nanocapsules : Ready-to-use nanovectors for the aerosol delivery of paclitaxel. European Journal of Pharmaceutics and Biopharmaceutics 2009, 73, 239-246.

Roger, E., Lagarce, F. and Benoit, J. P. The gastrointestinal stability of lipid nanocapsules. International Journal of Pharmaceutics 2009, 379, 260-265.

Roger, E., Lagarce, F., Garcion, E. and Benoit, J. P. Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis. Journal of Controlled Release 2009, 140, 174-181.

Werner, S., Huck, O., Frisch, B., Vautier, D., Elkaim, R., Voegel, J. C., Brunel, G. and Tenenbaum, H. The effect of microstructured surfaces and laminin-derived peptide coatings on soft tissue interactions with titanium dental implants. Biomaterials 2009, 30, 2291-2301.