Publications récentes


Automated linkage of proteins and payloads producing monodisperse conjugates
I. Dovgan, A. Hentz, O. Koniev, A. Ehkirch, S. Hessmann, S. Ursuegui, S. Delacroix, M. Riomet, F. Taran, S. Cianférani, S. Kolodych, A. Wagner, Chem. Sci., 2020, Advance Article.


Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents
I. Dovgan, O. Koniev, S. Kolodych, A. Wagner, Bioconjugate Chem., 2019, 30, 2483.

Design and evaluation of ionizable peptide amphiphiles for siRNA delivery
P. Neuberg, A. Wagner, J.-S. Remy, A. Kichler, Int. J. Pharm., 2019, 566, 141.

Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging
L. Plougastel, M. R. Pattanayak, M. Riomet, S. Bregant, A. Sallustrau, M. Nothisen, A. Wagner, D. Audisio, F. Taran, Chem. Commun., 2019, 55, 4582.


Synthesis and Kinetic evaluation of an azido analogue of methylerythritol phosphate: a Novel Inhibitor of E. coli YgbP/IspD
Z. Baatarkhuu, P. Chaignon, F. Borel, J.-L. Ferrer, A. Wagner, M. Seemann, Scientific Reports, 2018, 8, 17892.

Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing
M. Ripoll, M. Pierdant, P. Neuberg, D. Bagnard, A. Wagner, A. Kichler, J.-S. Remy, RSC Adv., 2018, 8, 20758.

Expedient synthesis of trifunctional oligoethyleneglycol-amine linkers and their use in the preparation of PEG-based branched platforms.
S. Ursuegui, J. P. Schneider, C. Imbs, F. Lauvoisard, M. Dudek, M. Mosser, A. Wagner, Org. Biomol. Chem., 2018, 16, 8579.

Recent, non-classical, approaches to antibody lysine modification.
G. Chaubet, F. Thoreau, A. Wagner, Drug Discov. Today Technol., 2018, DOI: 10.1016/j.antiviral.2018.04.005PANIST.


Inhibition of dengue virus infection by mannoside glycolipid conjugates.
E. Schaeffer, V. Flacher, P. Neuberg, A. Hoste, A. Brulefert, J.-D. Fauny, A. Wagner, C. G. Mueller, Antivir. Res., 2018, 154, 116-123.

Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates.
O. Koniev, I. Dovgan, B. Renoux, A. Ehkirch, J. Eberova, S. Cianférani, S. Kolodych, S. Papot, A. Wagner, Med. Chem. Commun., 2018, 9, 827-830.

Graphical abstract: Reduction–rebridging strategy for the preparation of ADPN-based antibody–drug conjugates

Arginine-selective bioconjugation with 4-azidophenyl glyoxal: application to the single and dual functionalisation of native antibody.
I. Dovgan, S. Erb, S. Hessman, S. Ursuegui, C. Michel, C. Muller, G. Chaubet, S. Cianférani, A. Wagner, Org. Biomol. Chem., 2018, 16, 1305-1311.

Graphical abstract: Arginine-selective bioconjugation with 4-azidophenyl glyoxal: application to the single and dual functionalisation of native antibodies

Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery.
P. Neuberg, I. Hamaidi, D. Danilin, M. Ripoll, V. Lindner, M. Nothisen, A. Wagner, A. Kichler, T. Massfelder, J.-S. Remy, Nanoscale, 2018, 10, 1587-1590.

Graphical abstract: Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery


Structural investigation of cyclo-dioxo maleimide cross-linkers for acid and serum stability.
E. Tobaldi, I. Dovgan, M. Mosser, J.-M. Becht, A. Wagner, Org. Biomol. Chem., 2017, 15, 9305-9310.


Discovery of new click and release reactions by screening of mesoionics and cycloalkynes combinations.
​F. Taran, S. Bernard, D. Audisio, M. Riomet, S. Bregant, A. Sallustrau, L. Plougastel, E. Decuypere, S. Gabillet, R. A. Kumar, J. Elyian, M. Nguyet Trinh, O. Koniev, A. Wagner, S. Kolodych, Angew. Chem. Int. Ed., 2017, 56, 15612–15616.


Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates.
​S.Kolodych, C. Michel, S. Delacroix, O. Koniev, A. Ehkirch, J. Eberova, S. Cianférani, B. Renoux, W. Krezel, P. Poinot, C. D. Muller, S. Papot, A. Wagner, Eur. J. Med. Chem., 2017, 142, 376-382.

An in vivo strategy to counteract post-administration anticoagulant activity of azido-warfarin.
S. Ursuegui, M. Recher, W. Krężel, A. Wagner, Nature Comm., 2017, 8, 15242.

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Acyl fluorides: fast, efficient, and versatile lysine-based protein conjugation via plug-and-play strategy.
I. Dovgan, S. Ursuegui, S. Erb, C. Michel, S. Kolodych, S. Cianférani, A. Wagner, Bioconjugate Chem., 2017, 28, 1452-1457.



pH-Responsive nanometric polydiacetylenic micelles allow for efficient intracellular siRNA delivery.
M. Ripoll, P. Neuberg, A. Kichler, N. Tounsi, A. Wagner, J.-S. Remy, ACS Appl. Mater. Interfaces, 2016, 8, 30665–30670.


​Copper-free click chemistry for microdroplet’s W/O interface engineering.
S. Ursuegui, M. Mosser, A. Wagner, RSC Advances, 2016, 6, 94942 – 94948.

Graphical abstract: Copper-free click chemistry for microdroplet's W/O interface engineering

​Ultrafast click chemistry with fluorosydnones.
H. Liu, D. Audisio, L. Plougastel, E. Decuypere, D.-A. Buisson, O. Koniev, S. Kolodych, A. Wagner, M. Elhabiri, A. Krzyczmonik, S. Forsback, O. Solin, V. Gouverneur, F. Taran, Angew. Chem. Int. Ed., 2016, 55, 12073 –12077.


2-(Maleimidomethyl)-1,3-dioxanes (MD): a serum-stable self-hydrolysable hydrophilic alternative to classical maleimide conjugation.
I. Dovgan, S. Kolodych, O. Koniev, A. Wagner, Sci. Rep., 2016, 6, 30835-30840.


Palladium catalyzed chemoselective and biocompatible functionalization of cysteine-containing molecules at room temperature.
R. Ahmed Atto Al-Shuaeeb, S. Kolodych, O. Koniev, S. Delacroix, S. Erb, S. Nicolaÿ, J-C. Cintrat, J.-D. Brion, S. Cianférani, M. Alami, A. Wagner, S. Messaoudi, Chem. Eur. J., 2016, 22, 11365 – 11370.


From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: a rational approach towards improved cleavable linkers for biospecific endosomal release.
S. A. Jacques, G. Leriche, M. Mosser, M. Nothisen, C. D. Muller, J.-S. Remy, A. Wagner, Org. Biomol. Chem., 2016, 14, 4794–4803.

Graphical abstract: From solution to in-cell study of the chemical reactivity of acid sensitive functional groups: a rational approach towards improved cleavable linkers for biospecific endosomal release


Mannoside glycolipid conjugates display anti-inflammatory activity by inhibition of toll-like receptor-4 mediated cell activation.
V. Flacher, P. Neuberg, F. Point, F. Daubeuf, Q. Muller, D. Sigwalt, J.D. Fauny, J.-S. Remy, N. Frossard, A. Wagner, C. G. Mueller, E. Schaeffer, ACS Chem. Biol., 2015, 10, 2697–2705.

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MAPN: first-in-class reagent for kinetically resolved thiol-to-thiol conjugation.
O. Koniev, S. Kolodych, Z. Baatarkhuu, J.Y. Bonnefoy, A. Wagner, Bioconjugate Chem., 2015, 26, 1863–1867.

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Spiro di-orthoester (SpiDo), a human plasma stable acid-sensitive cleavable linker for lysosomal release.
G. Leriche, S. A. Jacques, M. Nothisen, N. Baumlin, C. D. Muller, D. Bagnard, J.-S. Remy, A. Wagner, Bioconjugate Chem., 2015, 26, 1461-1465.

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Photopolymerized micelles of diacetylene amphiphile: physical characterization and cell delivery properties.
P. Neuberg, A. Périno, E. Morin-Picardat, N. Anton, Z. Darwich, D. Weltin, Y. Mely, A. S. Klymchenko, J.-S. Remy, A. Wagner, Chem. Commun., 2015, 51, 11595-11598.

Graphical abstract: Photopolymerized micelles of diacetylene amphiphile: physical characterization and cell delivery properties

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation.
O. Koniev, A. Wagner, Chem. Soc. Rev., 2015, 44, 5495-5551.

Graphical abstract: Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

Discovery of potent inhibitors of Schistosoma mansoni NAD+ catabolizing enzyme.
S. A. Jacques, I. Kuhn, O. Koniev, F. Schuber, F. E. Lund, A. Wagner, H. Muller-Steffner, E. Kellenberger, J. Med. Chem., 2015, 58, 3582–3592.

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CBTF: new amine-to-thiol coupling reagent for preparation of antibody conjugates with increased plasma stability.
S. Kolodych, O. Koniev, Z. Baatarkhuu, J.Y. Bonnefoy, F. Debaene, S. Cianférani, A. Van Dorsselaer, A. Wagner, Bioconjugate Chem., 2015, 26, 197–200.

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Development of models for prediction of the antioxidant activity of derivatives of natural compounds.PANIST
R. Martinčič; I. Kuzmanovski, A. Wagner, M. Novic, Anal. Chim. Acta, 2015, 868, 23–35.



4-Halogeno-sydnones for fast strain promoted cycloaddition with cyclooctynes.
L. Plougastel, O. Koniev, S. Specklin, E. Decuypere, C. Créminon, D. Buisson, A. Wagner, S. Kolodych, F. Taran, Chem. Commun., 2014, 50, 9376-9378.

Bio-specific and bio-orthogonal chemistries to switch-off the quencher of a FRET-based fluorescent probe: application to living-cell biothiol imaging.
C. Egloff, D. Weltin, C. Calligaro, M. Mosser, M. Nothisen, J.-S. Rémy, A. Wagner. Chem. Commun., 2014, 50, 10049-10051.

Developments in the field of bioorthogonal bond forming reactions — past and present trends.
M. King, A. Wagner, Bioconjugate Chem., 2014, 25, 825–839.

Copper-chelating azides for efficient click conjugation reactions in complex media.
V. Bevilacqua, M. King, M. Chaumontet, M. Nothisen, S. Gabillet, D. Buisson, C. Puente, A. Wagner, F. Taran, Angew. Chem. Int. Ed., 2014, 126, 5982–5986.

Selective irreversible chemical tagging of cysteine with 3-arylpropiolonitriles.
O. Koniev, G. Leriche, M. Nothisen, J.-S. Remy, J.-M. Strub, C. Schaeffer-Reiss, A. Van Dorsselaer, R. Baat, A. Wagner, Bioconjugate Chem., 2014, 25, 202–206.

Probing the catalytic mechanism of bovine CD38/NAD+glycohydrolase by site-directed mutagenesis of key active site residues.
I. Kuhn, E. Kellenberger, C. Cakir-Kiefer, H. Muller-Steffner, F. Schuber, Biochim. Biophys. Acta, 2014, 1317-1331​.


Schistosoma mansoni NAD+ catabolizing enzyme : identification of key residues in catalysis.
I. Kuhn, E. Kellenberger, F. Schuber, H. Muller-Steffner, Biochim. Biophys. Acta, 2013, 1834, 2520-2527.

Dynamic micelles of mannoside glycolipids are more efficient than polymers for inhibiting HIV-1 trans-infection.
E. Schaeffer, L. Dehuyser, D. Sigwalt, V. Flacher, S. Bernacchi, O. Chaloin, J.-S. Remy, C. G. Mueller, R. Baati, A. Wagner, Bioconjugate Chem., 2013, 24, 1813-1823.

A new series of Cs+, K+ and Na+ chelators: synthesis, kinetics, thermodynamics and modeling.PANIST
A. Korovitch, A. Le Roux, F. Barbault, M. Hemadi, N.-T. Ha-Duong, C. Lion, A. Wagner, J.-M. El Hage Chahine, Inorg. Chim. Acta, 2013, 394, 45-57.


Towards a KCC2 blocker pharmacophore model.
F. Lebon, C. Pegurier, M. Ledecq, B. Mathieu, N. Bosman, A. Frycia, S. Lengelé, K. Dhurke, A. K. Kanduluru, S. Meunier, A. Wagner, L. Provins, Bioorg. Med. Chem. Lett., 2012, 22, 3978-3982.

First steps towards conformationally selective artificial lectins: the chair-boat discrimination by molecularly imprinted polymers.
V. Lemau de Talance, O. Massinon, R. Baati, A. Wagner, S. P. Vincent, Chem. Commun., 2012, 48, 10684-10686.

New tetramethylthiepinium (TMTI) for copper-free click chemistry.
M. King, R. Baati, A. Wagner, Chem. Commun., 2012, 48, 9308-9309.

Synthesis of novel mannoside glycolipid conjugates for inhibition of HIV-1 trans-infection.
L. Dehuyser, E. Schaeffer, O. Chaloin, C. G. Mueller, R. Baati, A. Wagner, Bioconjugate Chem., 2012, 23, 1731–1739.

Capillary electrophoresis–inductively coupled plasma-mass spectrometry hyphenation for the determination at the nanogram scale of metal affinities and binding constants of phosphorylated ligands.
F. Varenne, M. Bourdillon, M. Meyer, Y. Lin, M. Brellier, R. Baati, L. J. Charbonnière, A. Wagner, E. Doris, F. Taran, A. Hagège, J. Chromatogr. A, 2012, 1229, 280–287.

A FRET-based probe with a chemically deactivatable quencher.
G. Leriche, G. Budin, Z. Darwich, D. Weltin, Y. Mély, A. S. Klymchenko, A. Wagner, Chem. Commun., 2012, 48, 3224-3226.

Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-Ray structures of its Michaelis Complex and covalently-trapped intermediates.
P. Egea, H. Muller-Steffner, I. Kuhn, C. Cakir-Kiefer, N. J. Oppenheimer, R. M. Stroud, E. Kellenberger, F. Schuber, PLOS One, 2012, 7, 34918.

Mild chemo-selective hydration of terminal alkynes catalyzed by AgSbF6.
M. Bui The Tong, A. Mann, A. Wagner, Chem. Commun., 2012, 48, 434-436.

Trimethoxyarene, a highly ionisable tag for reaction analysis by APPI/MS: exploration of heterocyclic synthesis.
M. Bui The Thuong, C. Catala, C. Colas, C. Schaeffer, A. Van Dorsselaer, A. Mann, A. Wagner, Eur. J. Org. Chem., 2012, 85-92.

Cleavable linkers in chemical biology.PANIST
G. Leriche, L. Chisholm, A. Wagner, Bioorg. Med. Chem., 2012, 20, 571-582.


Flavonoids as inhibitors of human CD38.PANIST
E. Kellenberger, I. Kuhn, F. Schuber, H. Muller-Steffner, Bioorg. Med. Chem. Lett., 2011, 21, 3939-3942.

Cationic polydiacetylene micelles for gene delivery.
E. Morin, M. Nothisen, A. Wagner, J.-S. Remy, Bioconjugate Chem., 2011, 22, 1916–1923.

Self-assembled nanotubes and helical tapes from diacetylene nonionic amphiphiles. Structural studies before and after polymerization.
A. Perino, M. Schmutz, S. Meunier, P. Mésini, A. Wagner., Langmuir, 2011, 27, 12149–12155.

Structure/function studies of DNA gyrase supramolecular complexes.
J. Papillon, N. Potier, C. Crucifix, J. F. Menetret, C. Genet, P. Oudet, A. Wagner, P. Schultz, V. Lamour, FEBS Journal, 2011, 278 (Suppl. 1), 472.

Design and synthesis of new antioxidants predicted by the model developed on a set of pulvinic acid derivatives.
A. Le Roux, I. Kuzmanovski, D. Habrant, S. Meunier, P. Bischoff, S. Thetiot-Laurent, T. Le Gall, A. Wagner, M. Novic, J. Chem. Inf. Model., 2011, 51, 3050–3059.

Stereoselective addition of Grignard reagents to new P-chirogenic N-phosphinoylbenzaldimines: effect of the phosphorus substituents on the stereoselectivity.
I. N. Francesco, C. Egloff, A. Wagner, F. Colobert, Eur. J. Org. Chem., 2011, 20-21.

Design, synthesis and evaluation of new α-nucleophiles for the hydrolysis of organophosphorus nerve agents: application to the reactivation of phosphorylated acetylcholinesterase.
G. Saint-André, M. Kliachyna, S. Kodepelly, L. Louise-Leriche, E. Gillon, P.-Y. Renard, F. Nachon, R. Baati, A. Wagner, Tetrahedron, 2011, 67, 6352-6361.

A representation to apply usual data mining techniques to chemical reactions— Illustration on the rate constant of SN2 reactions in water.
F. Hoonakker, A. Varnek, N. Lachiche, A. Wagner, Int. J. Artif. Intell. Tools, 2011, 20, 253-270.

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
G. Mercey, T. Verdelet, G. Saint-André, E. Gillon, A. Wagner, R. Baati, L. Jean, F. Nachon, P.-Y. Renard, Chem. Commun., 2011, 47, 5295-5297.

Programmed dispersions of MWNTs in aqueous media by coating with photopolymerizable synthetic amphiphiles.
C. Thauvin, A. Perino, E. Contal, E. Morin, P. Schultz, S. Meunier, A. Wagner, J. Phys. Chem. C, 2011, 115, 7319–7322.

Synthesis and radioprotective properties of pulvinic acid derivatives.
A. Le Roux, S. Meunier, T. Le Gall, J.-M. Denis, P. Bischoff, A. Wagner, ChemMedChem, 2011, 6, 561-569.

Cationic cyclization of 2-alkenyl-1,3-dithiolanes: diastereoselective synthesis of trans-decalins.
S. Goncalves, S. Santoro, M. Nicolas, A. Wagner, P. Maillos, F. Himo, R. Baati, J. Org. Chem., 2011, 76, 3274-3285.

Core functionalization of polydiacetylene micelles by a « click » reaction.
E. Contal, A. S. Klymchenko, Y. Mely, S. Meunier, A. Wagner, Soft Matter, 2011, 7, 1648-1650.

Tailoring drug release profile of low-molecular-weight hydrogels by supramolecular co-assembly and thiol-ene orthogonal coupling.
D. D. Díaz, E. Morin, E. M. Schön, G. Budin, A. Wagner, J.-S. Remy, J. Mater. Chem., 2011, 21, 641-644.

Structure and behaviour of polydiacetylene-based micelles.
A. Perino, A. S. Klymchenko, A. Morere, E. Contal, A. Rameau, J.-M. Guenet, Y. Mély, A. Wagner, Macromol. Chem. Phys., 2011, 212, 111-117.

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