Background: Conflicting results have been reported in studies of predictive factors for airway responsiveness to allergens during bronchial challenges.
Objective: The aim of this study was to assess determinants of airway responsiveness to 3 different allergens during standardized bronchial challenges.
Methods: Data were collected from asthmatic patients who participated in allergen challenge trials between 2000 and 2006 (cat, n=37; house dust mite [HDM], n=35; grass pollen, n=27). PD20 (provocative dose causing a 20% fall in forced expiratory volume in the first second) methacholine, PD20 allergen, allergen skin test endpoint, allergen-specific immunoglobulin (Ig) E levels, and late asthmatic response were analyzed for each allergen group.
Results: During the early asthmatic response, a significant relationship was found between PD20 allergen and PD20 methacholine (P