Polydiacetylenic nanofibers as new siRNA vehicles for in vitro and in vivo delivery, Nanoscale, 2018, 4, 1587-1590.

Polydiacetylenic nanofibers (PDA-Nfs) obtained by photo- polymerization of surfactant 1 were optimized for intracellular delivery of small interfering RNAs (siRNAs). PDA-Nfs/siRNA com- plexes efficiently silenced the oncogene Lim-1 in the renal cancer cells 786-O in vitro. Intraperitoneal injection of PDA-Nfs/siLim1 downregulated Lim-1 in subcutaneous tumor xenografts obtained with 786-O cells in nude mice. Thus, PDA-Nfs represent an innova- tive system for in vivo delivery of siRNAs.