Which Place for the Nlrp3 Inflammasome in the Msu Crystal-Induced Inflammatory Response in Vivo? Annals of the rheumatic diseases 2018, 77, A13-A13.

Our data seem to confirm that the PKD-NLRP3 axis exerts a major role in sensing MSU crystals in vitro but the relevance of this pathway in our in vivo gouty arthritis models is not so clear. We speculate that an alternative pathway could compensate for the loss of IL-1b in NLRP3 inflammasome- deficient mice. Unravelling this possibility might be of major fundamental interest and could even lead to new therapeutics in the field of inflammation.